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Article Summary
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Manlhiot C et al. - A substantial number of juvenile dermatomyositis (JDM) pts have a clinical history consistent with an infection prior to onset. Newly diagnosed patients should undergo a full infectious disease assessment. Methods- Aim was to correlate preceding infectious symptoms with onset and outcomes of JDM
- An inception cohort of all JDM cases was studied
- Data pertaining to symptoms at onset, diagnosis and disease outcomes were abstracted
- Two independent paediatric infectious disease specialists reviewed all records of pts with symptoms or tests suggestive of infection
Results- 78/110 pts had sufficient information about disease onset for inclusion
- Potential indications of an infectious process prior to JDM onset were found in 71% pts
- These pts were further evaluated for evidence of infection temporally associated with symptom onset
- Features suggestive of infection prior to JDM symptom onset were found in 40/55
- 80% of children with probable infections had respiratory illnesses
- Fewer pts than expected had disease onset during summer mos
- The presence of an infection at onset was not found to be associated with differences in characteristics at diagnosis or disease outcomes
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