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See Latest ArticlesCo-prescribing of proton pump inhibitors among chronic users of NSAIDs in the UK
Rheumatology, 03/28/08
Suh DC et al. - Proton pump inhibitors (PPI) utilization correlates poorly with nsNSAID use in the UK. GI safety of nsNSAID–PPI co-therapy observed in controlled trials may therefore not be achieved in clinical practice.
Methods- Aim was to estimate usage of PPI co-therapy among chronic nsNSAID users and to determine factors associated with concurrent nsNSAID–PPI use
- Study included subjects >=40 y of age who received their first oral nsNSAID prescription and who had >=60 d of nsNSAID supply during the following year
- Days with nsNSAID–PPI overlap were calculated and logistic regression was used to identify factors associated with nsNSAID–PPI overlap
- A generalized linear model was used to assess the degree of association of GI risk factors with the nsNSAID–PPI overlap ratio among PPI users
- 1,586/16,344 pts received at least one PPI prescription
- Among PPI users, PPIs were available on ~50% of the days with nsNSAID therapy
- Age >=65 y, history of any hospitalization and co-prescriptions for anti-coagulants or oral corticosteroids increased the odds of any nsNSAID–PPI overlap by 21–68%
- Prior gastroprotective agent (GPA) use increased the odds of any PPI use during f/u 16-fold and nsNSAID–PPI overlap 19-fold
- Among PPI users, pts with prior use of any GPA had a 2.46 times higher nsNSAID–PPI overlap ratio
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