Sellam J et al. - Inhibitor of differentiation 3 (Id3) expression is not impaired in salivary glandular epithelial cells (SGECs), peripheral T cells and in labial salivary glands in Sjögren's syndrome (pSS) pts. Id3-relevant single nucleotide polymorphisms (SNPs) do not give evidence of genetic predisposition in Caucasian pSS patients. Methods
A study to investigate the role of Id3 in human pSS
Quantitative Id3 expression in peripheral T cells, cultured SGECs and in total minor salivary glands was assessed by RT-PCR in pSS pts and controls
After Id3 sequencing, two SNPs in a case–control study of 212 Caucasian pSS pts and 168 controls was investigated
Results
Quantitative Id3 expression was not decreased in pSS pts nor in SGECs, in T cells or in minor salivary glands
Pts and controls did not differ in allele and genotype frequencies of Id3 SNPs
Neither SNP was associated with a pattern of autoantibody secretion
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