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Serum uric acid: Novel prognostic factor in primary systemic amyloidosis
Mayo Clinic Proceedings, 03/06/08

Kumar S et al. - The data presented in this study confirm the prognostic utility of cardiac troponin T (cTnT) and N-terminal propeptide of brain-type natriuretic peptide (NTProBNP) in a large group of patients and highlight the value of serum uric acid (UA) in allowing better forecasting of probable outcomes for patients with amyloidosis (AL).

Methods

Aim was to determine the prognostic value of serum UA in pts with primary systemic AL
A cohort of 1977 pts with newly diagnosed AL, and 293 pts with AL who underwent peripheral blood stem cell transplant were studied retrospectively to examine the value of serum UA
The prognostic value of several variables was examined, and the survival time was estimated

Results

Pts with UA levels greater than 8 mg/dL had a median OS of 9 mos from diagnosis vs. 20.3 mos for the remaining pts
The prognostic value of UA was independent of the known cardiac prognostic markers cTnT and NTProBNP
Pts with none, 1, 2, or 3 of these risk factors (UA, >8 mg/dL; cTnT, >0.035 ng/mL; and NTProBNP, >332 pg/mL) had a median OS of 36.6, 29.2, 11.1, and 3.6 mos, respectively
Similarly, UA levels helped predict OS in pts undergoing peripheral blood stem cell transplant for AL and added to the value of cTnT and NTProBNP

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