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Gender-related risk of myocardial involvement in systemic amyloidosis
Amyloid The Journal of Protein Folding Disorders, 02/14/08
Rapezzi C et al. - Findings in this study raise the hypothesis that some biological characteristic associated with female gender protects against myocardial involvement in familial transthyretin-related amyloidosis (ATTR).
Methods- Aim was to investigate associations between gender and myocardial involvement in systemic amyloidosis
- 100 AL and 98 familial ATTR pts, plus 12 elderly men with senile systemic amyloidosis were reviewed
- Focus was on echocardiographic descriptors of myocardial involvement, wall thickness, and baseline LV function
- Among familial ATTR pts, female prevalence was lower within the highest tertile of either echocardiographic indicator of myocardial involvement
- Gender was independently associated with height-indexed mean LV wall thickness
- Female prevalence appeared rather similar across the different neurological stages
- Within the subgroup of familial ATTR pts with amyloidotic cardiomyopathy, women tended to display a considerably less severe morphological and functional echocardiographic profile
- Women in the highest tertile of mean LV wall thickness index were more often postmenopausal and had a much higher mean age
- Analogous age-related associations were not observable for men
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