Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Rapid correction of low vitamin D status in nursing home residents 3. 2008 Exclusive Survey—Earnings: Good news for primary care income 4. Medicare pay-for-reporting effort draws fire from frustrated doctors 5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Top Ten Searches
rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
See Latest ArticlesHigher therapeutic plasma oxypurinol concentrations might be required for gouty patients with chronic kidney disease
Journal of Clinical Rheumatology (JCR), 02/11/08
Panomvana D et al. - Higher percentages of patients could meet the treatment goal when their plasma oxypurinol concentrations were higher than the proposed therapeutic range for patients with normal renal function.
Methods- This study was performed to examine the relationships between plasma oxypurinol conc and the changes in serum urate level and renal function after taking a standard dose of allopurinol, 300 mg daily, in gout pts (n=27) with renal insufficiency
- Both new and current pts, after they discontinued allopurinol completely for 4 wks, were treated with allopurinol 300 mg/dx6wks
- Blood samples were collected before and 5 h after the studied dose had been taken
- Serum urate levels and renal function were recorded before and after the treatment
- Plasma oxypurinol conc were higher than the proposed therapeutic range for pts with normal renal function
- Relationships existed between changes in serum urate level with both trough and fifth-hour oxypurinol concs
- Higher plasma oxypurinol concs resulted in a higher percentage of pts who could meet the therapeutic treatment goal
- No serious side effect and no significantly change in creatinine clearance were observed
- Thus high levels of oxypurinol did not appear to relate to higher prevalence of adverse reaction
Today in Gout and Hyperuricemia...keeping you current
Receive free subspecialty "5-minute updates" via email
Hyperuricemia Is a Mediator of Endothelial Dysfunction and Inflammation in Renal Allograft Recipients
Transplantation Proceedings, 11/02/09
Prescription and comorbidity screening following consultation for acute gout in primary care
Rheumatology, 11/23/09
Common Polymorphisms Influencing Serum Uric Acid Levels Contribute to Susceptibility to Gout, but Not to Coronary Artery Disease
PLoS ONE - Cardiovascular Disorders, 11/10/09
Sponsor
Article Search
Sponsor