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Risk factors associated with acute hip prosthetic joint infections and outcome of treatment with a rifampin-based regimen
Acta Orthopaedica, 02/08/08

Choong PFM et al. - Primary joint replacement was salvaged in 11 of 14 patients with prolonged rifampicin-based antibiotic therapy. When successful reimplantation was included, 13 of 14 patients had a mobile prosthetic joint without further infection.

Methods

A study to report factors related to acute infection and results of combined joint debridement and prolonged rifampicin-based antibiotic therapy
14 acute infections that occurred after 819 primary hip arthroplasties were studied
The association between patient-related and surgical factors and the risk of infection were analyzed
Infections were treated with multiple joint lavage, debridement, 2 wks of antibiotic therapy, and then oral antibiotics for a minimum of 6 mos

Results

A correlation existed between having a body mass index (BMI) of >=30, >2 co-morbidities, and an increased risk of infection
Diabetes was a potential risk factor
Following the regime of treatment, 11/14 pts retained their prosthesis
2/3 who required resection arthroplasty underwent successful staged revision

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