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Clinical experience with daptomycin for the treatment of patients with documented gram-positive septic arthritis
Annals of Pharmacotherapy, 02/06/08

Forrest GN et al. - Daptomycin was effective when used as part of a treatment regimen for septic arthritis, however this observation requires verification via a prospective clinical trial.

Methods

A retrospective, observational, multicenter study, to describe the clinical use of daptomycin
Efficacy of daptomycin therapy was determined as cure, improved, failure, or nonevaluable
Pts who had a diagnosis of septic arthritis confirmed by positive culture or deep tissue biopsy, were selected (n=22)

Results

Staphylococcus aureus was the most common pathogen, with the majority resistant to methicillin
All pts received an antibiotic prior to daptomycin; in 7 pts, at least one of the prior antibiotics was continued with daptomycin
2/3 of pts received an antibiotic with daptomycin; rifampin was the most common
The median final dose and duration of daptomycin therapy were 5 mg/kg and 22 days respectively
82% of pts received daptomycin as inpatient and 68% as an outpatient
Cure or improved were reported in 41% and 50% of the pts, respectively
2 adverse events were reported; neither related to daptomycin

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