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Regulation of Sox9 activity by crosstalk with NF-kappaB and retinoic acid receptors
Arthritis Research & Therapy, 01/10/08

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Free Abstract

Rockel JS et al. - Sox9 and p300 co-operate to induce expression of cartilage-specific matrix proteins, including type II collagen, aggrecan and link protein. Tumor necrosis factor-a (TNF-a), found in arthritic joints, activates NF-kB, whereas retinoic acid receptors (RARs) are activated by retinoid agonists including all-trans retinoic acid (atRA)

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