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The inflammasome, autoinflammatory diseases, and gout
Joint, Bone, Spine, 12/17/07

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Petrilli, V., et al. - IL-1beta is a cytokine with major roles in inflammation and innate immune responses. IL-1beta is produced as an inactive proform that must be cleaved within the cell to generate biologically active IL-1beta. The enzyme caspase-1 catalyzes the reaction. Recent work showed that caspase-1 must be activated by a complex known as the inflammasome

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