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See Latest ArticlesSafety, Tolerability, and Effects on Plasma and Cerebrospinal Fluid Amyloid-[beta] After Inhibition of [gamma]-Secretase
Clinical Neuropharmacology, 12/07/07
Siemers, E.R., eta l. - [gamma]-Secretase inhibitors may be useful as disease-modifying drugs for the treatment of Alzheimer disease. LY450139 is a [gamma]-secretase inhibitor currently in clinical development, with doses being optimized through the use of biomarkers...These data show that single doses of LY450139 up to 140 mg are accompanied by a dose-dependent plasma A[beta] response. No response in CSF A[beta] was apparent 4 hours after dosing
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Short and long-term outcome of treatment with high-dose melphalan and stem cell transplantation for multiple myeloma-associated AL amyloidosis
Annals of Hematology, 12/18/09
Clinical features and functional significance of the P369S/ R408Q variant in pyrin, the familial Mediterranean fever protein
Annals of Rheumatic Diseases, 12/11/09
MEFV mutations in Egyptian patients suffering from familial Mediterranean fever: analysis of 12 gene mutations
Rheumatology International, 10/16/09
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