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See Latest ArticlesProgression of cardiac amyloid deposition in hereditary transthyretin amyloidosis patients after liver transplantation
Amyloid The Journal of Protein Folding Disorders, 11/02/07
Liepnieks, J.J., et al. - It has been hypothesized that transthyretin (TTR) amyloidosis may progress after orthotopic liver transplantation (OLT) as a result of continued amyloid fibril synthesis and deposition from normal TTR. To test this hypothesis amyloid fibrils were isolated from cardiac tissues of three patients who died 1.5 to 5.5 years after OLT: two with Val30Met and one with Thr60Ala TTR. The ratio of variant to normal TTR in each case was determined and compared with the ratio of variant to normal in cardiac tissues from seven patients who died with TTR amyloidosis but who had not had liver transplantation
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