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Arbez, N., et al. - In Alzheimer’s disease there is an increased production of the toxic Beta-amyloid peptides (Abeta), especially the longer forms such as Abeta(1–42). Using the patch–clamp technique we have studied the contribution of early pro-inflammatory processes to the acute effects of 1 microM Abeta(1–42) on the parallel fiber EPSC (PF-EPSC) of Purkinje cells in cerebellar slices. Abeta(1–42) induces a decrease in the PF-EPSC amplitude

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