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See Latest ArticlesTocilizumab: a new form of biological therapy for rheumatoid arthritis
Future Rheumatology, 10/01/07
Balint, G.P., et al. - Overactivity of IL-6 plays a very important role in both the exsudative and proliferative phase of rheumatoid inflammation, joint destruction and osteoporosis. Blocking of IL-6 activity is a rational goal in the treatment of rheumatoid arthritis (RA). Tocilizumab (TCZ) is a humanized antibody against the soluble IL-6 receptor (sIL-6R) and membrane-bound IL-6 receptor (mIL-6R), blocking these receptor complexes and preventing IL-6 transmembrane signaling
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Minimal influence of tocilizumab on IFN-gamma synthesis by tuberculosis antigen
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Will treatment of rheumatoid arthritis with an IL-6R inhibitor help facilitate the age of remission?
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ACTEMRA inhibits progression of joint destruction in RA patients by over 80% compared to methotrexate alone
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Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like synovial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modifying antirheumatic drugs
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Today in Amyloidosis...keeping you current
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Clinical features and functional significance of the P369S/ R408Q variant in pyrin, the familial Mediterranean fever protein
Annals of Rheumatic Diseases, 12/11/09
MEFV mutations in Egyptian patients suffering from familial Mediterranean fever: analysis of 12 gene mutations
Rheumatology International, 10/16/09
Classification of amyloidosis by laser microdissection and mass spectrometry based proteomic analysis in clinical biopsy specimens
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Today in Bone Metabolism...keeping you current
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No anti-angiogenic effect of clinical dosing regimens of a single zoledronic acid injection in an experimental bone healing site
Bone , 12/11/09
Poor bisphosphonate adherence for treatment of osteoporosis increases fracture risk: Systematic review and meta-analysis
Osteoporosis International, 12/10/09
The efficacy of calcitriol therapy in the management of bone loss and fractures: A qualitative review
Osteoporosis International, 12/10/09
Today in Clinical Pharmacology...keeping you current
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Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts
Rheumatology, 12/11/09
Poor bisphosphonate adherence for treatment of osteoporosis increases fracture risk: Systematic review and meta-analysis
Osteoporosis International, 12/10/09
The efficacy of calcitriol therapy in the management of bone loss and fractures: A qualitative review
Osteoporosis International, 12/10/09
Today in Rheumatoid Arthritis...keeping you current
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A new graph and scoring system simplified analysis of changing states: disease remissions in a rheumatoid arthritis clinical trial
Journal of Clinical Epidemiology, 12/11/09
Criterion Contamination of Depression Scales in Patients with Rheumatoid Arthritis: The Need for Interpretation of Patient Questionnaires (as All Clinical Measures) in the Context of All Information About the Patient
Rheumatic Disease Clinics of North America, 12/11/09
RAPID3, an Index to Assess and Monitor Patients with Rheumatoid Arthritis, Without Formal Joint Counts: Similar Results to DAS28 and CDAI in Clinical Trials and Clinical Care
Rheumatic Disease Clinics of North America, 12/11/09
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