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The rise and decline of nonsteroidal antiinflammatory drug-associated gastropathy in rheumatoid arthritis
Arthritis & Rheumatism, 08/12/04

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Conclusion: The risk of serious NSAID gastropathy has declined by 67% in these cohorts since 1992. We estimate that 24% of this decline was the result of lower doses of NSAIDs, while 18% was associated with the use of proton-pump inhibitors and 14% with the use of less toxic NSAIDs. These declines in the incidence of NSAID gastropathy are likely to continue

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