Temporary brittle bone disease: Fractures in medical care
Paterson CR et al. – This study reports 5 infants with typical features of temporary brittle bone disease in whom all or most of the fractures took place while in hospital. A non-accidental cause can be eliminated with some confidence. These findings are important in contributing to the evidence for the reality of a syndrome characterized by temporary bone fragility and should stimulate increased effort to identify the causes.- What is the nature of this condition?
- One possibility is osteogenesis imperfecta. However it seems unlikely, as it should have shown other good evidence for its existence
- Another possibility is vitamin D deficiency rickets, which is now recognized as much more common than previously thought
- Another possibility, at least in one case, is bone disease of prematurity
- Various metabolic and mechanical causes for this syndrome have also been reported
- One feature of this group of pts is the very large number of rib fractures which occurred under close medical supervision and without any other evidence of trauma
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