Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice
Elewaut D et al. – This review focuses on current progress in treatment options in ankylosing spondylitis (AS) with special emphasis on extra-articular features.- TNF inhibition has demonstrated effectiveness in the treatment of AS symptoms
- However, the efficacy of anti-TNF agents varies in the treatment of extra-articular manifestations and comorbidities
- Significant reductions in the incidence of flares of uveitis and IBD with infliximab and adalimumab (uveitis only) treatment have been shown, but not with etanercept
- All 3 anti-TNF agents (infliximab, adalimumab, etanercept) have demonstrated efficacy in psoriasis (not associated with AS)
- When evaluating as to which agent to use in the treatment of AS, an important consideration is the overall well-being of the patient
- To date, infliximab appears to be the best studied agent with a wide spectrum of proven efficacy
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