Immunopathogenesis of spondyloarthritis: Which cells drive disease?
Melis L et al. – This review summarises recent progress in ourunderstanding of the immunopathogenesis of spondyloarthritides (SpA) with special emphasis on the cellular constituents considered to be responsible for the initiation and/or perpetuation of inflammation.- There is ample evidence that bone marrow as well as stromal cells seem to be involved in SpA pathogenesis
- However, the interaction of these cell types remains to be established
- There are several arguments favouring a role for haematopoietic cells in thepathophysiology of spondyloarthritis, including:
- HLA-B27-associated dendritic cell disturbances
- HLA-B27 misfolding properties, and
- T helper 17 cells
- In addition, recent studies have pointed toward a pivotal role for stromal cells
- A major challenge, however, remains to determine how recently identified genetic associations such as IL-23 receptor polymorphisms may influence cellular targets in spondyloarthritis
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