Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: A prospective study of 124 cases
Zheng H et al. – Study reports that glomerular microthrombosis (GMT) occurs in approximately 20.2% of lupus nephritis (LN) patients. Patients with GMT have severer renal tissue injuries and poorer renal functions than patients without GMT. The lupus anticoagulant and antibodies against β2 glycoprotein I and thrombin may play a role in GMT. Methods- An investigation of the prevalence of GMT in LN pts and to examine the relationship between the aPL profiles and GMT
- Renal biopsy specimens were examined for the presence of glomerular microthrombi
- Plasma samples from 25 LN pts with GMT (LN-GMT group) and 99 LN pts w/o GMT (LN-non-GMT group) were tested for:
- lupus anticoagulant and Abs against cardiolipin,
- β2 glycoprotein I, plasmin, thrombin, tissue plasminogen activator, and annexin II
Results- Prevalence of GMT in LN pts was 20.2%
- Compared with the LN-non-GMT group, the LN-GMT group had:
- Elevated SLE disease activity index
- Elevated renal tissue injury activity and chronicity indices
- Elevated serum creatinine, blood urea nitrogen, and proteinuria levels
- Lower serum C3 level and much intense glomerular C3, C1q staining, and
- Higher frequency of hypertension
- Additionally, the detection rate of lupus anticoagulant, IgG anti-β2 glycoprotein I and anti-thrombin Abs were higher in the LN-GMT vs LN-non-GMT group
- No differences in the detection rates of IgG anti-cardiolipin, plasmin, tissue plasminogen activator (t-PA), or annexin II Abs
- No detectable difference in IgM Abs to the above antigens was observed between the 2 groups
[more...]
|
|
|
