Can Anatomic Alignment Measured from a Knee Radiograph Substitute for Mechanical Alignment from Full Limb Films Felson DT et al. - While agreement of alignment from knee x-ray to full limb film was only moderate, varus malalignment measured from a flexed knee predicted the likelihood of progression well. Flexed knee alignment may be more relevant to knee OA risk than that of a fully extended knee, but a measurement of alignment from a short limb is an imperfect surrogate for full limb alignment. [more...]