Noninvasive assessment of impaired endothelial function in psoriasis
Ulusoy RE et al. – Study demonstrates that noninvasive methods such as ultrasonography, saving time and cost-effective, can be utilized for following outpatient psoriasis disease (PD) patients for the risk of endothelial dysfunction (ED), which may preclude to atherosclerosis.Methods- Main objectives of this study were:
- Noninvasive assessment of endothelial dysfunction (ED) and
- Diagnosing the possible early vascular development of atherosclerosis
in psoriasis disease (PD)
- 28 PD pts (study group) w/o any obstructive vascular involvement, compared with 28 healthy controls (control group)
- Endothelium-independent dilation was assessed by measuring changes in brachial artery diameter following sublingual glyceryl trinitrate
- All pts underwent a complete transthoracic echocardiographic and tissue Doppler study
- A standard form was utilized for the documentation of the presence or absence of the known risk factors for atherosclerotic vascular disease
Results- No difference between pts and controls in terms of echocardiographic and tissue Doppler parameters, and baseline brachial artery diameters
- Flow-mediated dilation showed 37% impairment in study group vs control
- Endothelium-independent NTG dilatation did not differ in both groups
[more...]
|
|
|
