The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus
Chandrasekhara PKS et al. – Data provide evidence that the prevalence of poor sleep quality in patients with systemic lupus erythematosus (SLE) was higher than it is generally perceived to be. Functional disability, disease activity and depressed mood contributed significantly to sleep disturbances.Methods- An analysis of sleep complaints in pts with SLE and its prevalence and associations
- In 50 outpatients, and age- and sex-matched controls:
- Sleep quality assessed using the Pittsburgh Sleep Quality Index (PSQI)
- Depressed mood, functional disability and pain severity using standardized questionnaires
- Disease severity, cumulative damage and presence of fibromyalgia by clinical examination
- Bivariate associations between sleep quality and disease-related variables and demographic variables
- Hierarchical regression analyses to determine the independent determinant of sleep quality
Results- PSQI scores were higher in pts; prevalence of sleep disturbance was 62%
- Functional disability, disease activity and depressed mood correlated positively with sleep disturbances
- 36% of the pts satisfied ACR criteria for fibromyalgia
- Multiple regression analyses: disease activity was an independent determinant of sleep quality
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