Identification of candidate genes for susceptibility to reactive arthritis
Rihl M et al. - Gene expression data obtained from monocytes of ReA patients in remission identifies the highest ratios of the eight transcripts observed for the chemokine IP10 and the cytokine TNF-α. Methods- This study aimed at identifying mRNA transcripts in peripheral blood monocytes of ReA pts accounting for potential ReA susceptibility
- Gene expression profile in monocytes from 3 pts with reactive arthritis (ReA) in remission was evaluated
Results- Gene expression analyses revealed 8 differentially expressed mRNA transcripts
- The major part of genes encoded cytokines, growth factors and chemokines
- There was a remarkably high proportion of proangiogenic factors, in particular IP10, ENA-78, and IL-8 accounting for a genetically determined susceptibility to ReA at the host cell level
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