Can structural damage be prevented in ankylosing spondylitis
Sieper J - A better understanding of the interaction between inflammation and new bone formation on the molecular level indicate that inflammatory molecules such as TNF-alpha inhibit osteoblasts and that a TNF-blockade induces new bone formation. Thus, TNF-blockers can only be expected to prevent new bone formation if this is coupled to inflammation and if inflammation is treated early enough. Studies on bone biomarkers in ankylosing spondylitis patients support the view that suppression of inflammation induces new bone formation. [more...]
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