Efficacy and tolerance of rifampicin–linezolid compared with rifampicin–cotrimoxazole combinations in prolonged oral therapy for bone and joint infections
Nguyen S et al. – Data show that prolonged oral combination of rifampicin and linezolid (RLC) and combination of rifampicin and cotrimoxazole (RCC) therapy were equally effective in treating pts with bone and joint infections (BJI) caused by resistant Gram-positive cocci (GPC), including pts with infected orthopaedic devices. However, the lower cost of cotrimoxazole compared with linezolid renders RCC an attractive treatment alternative to RLC. Methods- Study to compare the efficacy and safety of RLC with those of RCC in the treatment of BJI
- Between Feb 2002 and Dec 2006, 56 adult pts were randomized to RLC, (n=28), and RCC (n=28), including:
- 36 with infected orthopaedic devices (RLC, n=18; RCC, n=18) and
- 20 with chronic osteomyelitis (RLC, n=10; RCC, n=10)
- Pts who discontinued antibiotic therapy within 4 wks of commencing treatment represented cases of treatment failure and were excluded
Results- Rates of occurrence of AEs were similar in the 2 groups
- It led to treatment discontinuation in 14.3% RLC and 21.4% RCC pts
- Cure rates were found to be similar in the 2 groups
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