Top lupus Articles in Rheumatology

Ten cases of systemic lupus erythematosus related to hepatitis B vaccine
Lupus, 11/09/2009

Agmon–Levin N et al. – The objective of this article is to identify common and atypical features of systemic lupus erythematosus diagnosed following hepatitis B vaccination. Systemic lupus erythematosus related to ... from idiopathic systemic lupus erythematosus in its clinical presentation and may resemble drug–induced systemic lupus erythematosus. Thus, physicians should be alerted to this potential association, its possible long latency period and unique presentations, and be encouraged to report and ... autoimmune/heritable,systemic lupus (sle) [more...]

Circulating CSF-1 Promotes Monocyte and Macrophage Phenotypes that Enhance Lupus Nephritis
Journal of the American Society of Nephrology, 11/20/2009

Menke J et al. – The found increased levels of CSF–1 in the serum, urine, and kidneys of patients with lupus compared with healthy controls. Serum and urine CSF–1 levels correlated with lupus activity, and intrarenal CSF–1 ... histopathology activity index of lupus nephritis. Circulating CSF–1 is a potential therapeutic target for lupus nephritis. [more...]

Developments in the clinical understanding of lupus
Arthritis Research & Therapy, 10/29/2009

Crow MK – Advances in genetics and new understanding of the molecular pathways that mediate innate and adaptive immune system activation, along with renewed focus on the role of the complement system as a mediator of inflammation, have ... pathogenesis of systemic lupus erythematosus. Progress in understanding the underlying immunopathogenesis of lupus and its impact on clinical disease has accelerated the pace of clinical research to improve the outcomes of patients with systemic lupus erythematosus. [more...]

Simultaneous herpes simplex virus esophagitis and lupus enteritis in a patient with systemic lupus erythematosus
Modern Rheumatology, 10/23/2009

Wakui H et al. – The authors present a 52–year–old woman with a 6–year history of systemic lupus erythematosus (SLE) developed acute abdominal pain, nausea ... hypocomplementemia. This is the first case of simultaneous HSV esophagitis and lupus enteritis. [more...]

Safety of vaccination of patients with systemic lupus erythematosus
Lupus, 11/04/2009

Abu–Shakra M – Vaccines may trigger the generation of autoantibodies which is usually short term and has no clinical significance. In individual cases vaccines exacerbate systemic lupus erythematosus; however, no specific ... identified to be associated with flare of systemic lupus erythematosus following vaccination. [more...]

Correlation of ESR, C3, C4, anti-DNA and lupus activity based on British Isles Lupus Assessment Group Index in patients of rheumatology clinic
Rheumatology International, 10/09/2009

Nasiri AS et al. – This study aimed to determine the correlation between of ESR, C3, C4, anti-DNA, and lupus activity and also the construct and criterion validity of the British Isles Lupus ... Assessment Group (BILAG) index for assessing disease activity in systemic lupus erythematosus (SLE).The findings show that the ESR, C3, C4, and anti-DNA should be used in the evaluation and management of patients with SLE. Also the results show that the BILAG index has construct validity. Data analyzed for estimating of SLE disease activity [scores on the BILAG index and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K)] Overall BILAG scores determined by highest score achieved in any of the individual systems in respective index Results Increasing overall scores on the BILAG index associated with increasing ESRs, decreasing C3 levels, decreasing C4 levels, elevated anti-dsDNA levels, and increasing SLEDAI-2K scores [more...]

Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis
Kidney International, 11/05/2009

Radhakrishnan J et al. – The authors found that the response to mycophenolate mofetil (MMF) as induction treatment of patients with class V lupus nephritis (LN) appears to be no different from that to intravenous ... pharmacology,glomerular/tubular dz,systemic lupus (sle),pharmacology/kinetics,nephrology [more...]

Infection—genetics relationship in systemic lupus erythematosus
Lupus, 11/05/2009

Sebastiani GD – Evidence has been emerging suggesting that the production of autoantibodies, by infected B–lymphocytes, may be drawn by altered expression of particular microRNA in these cells. In this paper, the authors ... can account for the role of infectious agents, acting on a genetically prone host, in determining systemic lupus erythematosus. [more...]

Regulatory T Cell (Treg) Subsets Return in Patients with Refractory Lupus following Stem Cell Transplantation, and TGF-[beta]-Producing CD8+ Treg Cells Are Associated with Immunological Remission of Lupus
Journal of Immunology, 11/10/2009

Zhang L et al. – Unlike conventional drug therapy, hemopoietic stem cell ... CD8TGF–? Treg cells, which repairs the Treg deficiency in human lupus to maintain patients in true immunological remission. [more...]

Vaccination, atherosclerosis and systemic lupus erythematosus
Lupus, 11/05/2009

Carvalho JF et al. – In non–systemic lupus erythematosus populations, vaccines against oxidized low–density lipoprotein, beta–2–glycoprotein I, heat shock proteins, lipoproteins, cholesterol, molecules ... receptor, and interleukin–2) have been tested, with promising results. However, there are no studies of vaccination against atherosclerosis in systemic lupus erythematosus. [more...]