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Mast cells are the main interleukin-17-positive cells in anti-citrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium Full Text
Arthritis Research & Therapy, 09/29/2011
Suurmond J et al. – The synovial mast cell is the main IL-17+ cell in all three arthritis groups analyzed. These data are relevant for studies aimed to block IL-17 in the treatment of arthritis.
Methods- Synovial samples of anti-citrullinated protein antibody-positive (ACPA) and -negative RA and osteoarthritis (OA) patients stained for IL-17 in combination with CD117 (mast cells), CD3 (T cells) and CD68 (macrophages)
- Concentrations of IL-17 in synovial fluid were determined by ELISA
- The number of IL-17+ cells in synovium is comparable in all groups
- Although vast majority of IL-17+ cells are mast cells, no difference in percentage of IL-17+ mast cells was observed
- Levels of IL-17 in synovial fluid were increased in ACPA+ RA compared to ACPA- RA and OA patients
