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Lower expression of histamine H4 receptor in synovial tissues from patients with rheumatoid arthritis compared to those with osteoarthritis
Rheumatology International, 09/07/2011
Clinical Article
Yamaura K et al. – This study supports the supposition that H4R in synovial tissue may play a role in cartilage and bone destruction by influencing the secretion of MMP-3 in patients with RA.
Methods- Synovial tissues obtained from 7 RA and 7 OA patients undergoing artificial arthroplasty
- Serum levels of ESR, CRP, matrix metalloproteinase-3 (MMP-3), rheumatoid factors, and cyclic citrullinated peptide antibodies were determined
- Expression of H4R mRNA in synovial tissues determined by real-time polymerase chain reaction
- Expression of H1R and H4R mRNA significantly lower in RA compared with OA patients (P < 0.005), while expression of H2R mRNA was comparable in both
- Significant negative correlation found between H4R expression and serum MMP-3 concentration (r = -0.70, P < 0.05), no correlation was found between MMP-3 and H1R (r = -0.52) or H2R (r = 0.23)
