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Interstitial lung disease and ANCA-associated vasculitis: A retrospective observational cohort study
Rheumatology, 08/30/2011
Clinical Article
Arulkumaran N et al. – It is important that physicians are aware of the clinical association and the presence of ILD should be considered in all patients with ANCA-associated vasculitis, especially those with MPO-ANCA. The possibility that patients with ILD may subsequently develop features of systemic vasculitis should also be remembered.
Methods- Retrospective observational cohort study
- Patients who presented to Hammersmith Hospital, London, with ANCA-associated vasculitis [granulomatosis with polyangiitis (Wegener's), microscopic polyangiitis (MPA) or Churg–Strauss syndrome] who also had ILD
- Following hospital discharge, all patients followed up in multi-disciplinary vasculitis clinic
- Recorded patient demographics, diagnostic tests, treatment, complications and mortality
- ILD observed in 2.7% (n=14) of patients with ANCA-associated vasculitis (n=510); all had MPO-ANCA and a clinical diagnosis of MPA, giving a prevalence of 7.2% in patients with MPA (n=194)
- No significant difference in survival between patients with MPA and ILD and those with MPA alone