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Idiopathic inflammatory myopathy associated with malignancy: A retrospective cohort of 151 Korean patients with dermatomyositis and polymyositis
Journal of Rheumatology, 08/22/2011
Clinical Article
So WS et al. – DM was associated with a greater risk of concomitant malignancies, especially lung cancer, than PM. Independent factors associated with malignancies in patients with DM/PM were older age, the presence of dysphagia, and the absence of ILD.
Methods- Demographic, clinical, and laboratory features of 151 patients diagnosed with DM/PM compared in patients with and without malignancies
- Malignancies were found in 23 of 98 patients with DM (23.5%) and in 2 of 53 with PM (3.8%)
- Lung cancer (8 patients) was the most common malignancy
- Compared with the period-specific, sex-matched, and age-matched Korean population, the SIR for malignancy in patients with DM was 14.2 (95% CI 9.0–21.3)
- Univariate analysis showed that factors associated with malignancy included older age (p < 0.001), DM (p = 0.002), dysphagia (p < 0.001), the absence of interstitial lung disease (ILD; p = 0.001), and lower elevations in aspartate aminotransferase (p = 0.005) and lactate dehydrogenase concentrations (p < 0.001)
- Multivariate analysis showed that factors independently associated with malignancy included older age (per 10 years, OR 2.3, 95% CI 1.6–3.5, p < 0.001), DM (OR 5.9, 95% CI 1.3–26.2, p = 0.020), dysphagia (OR 2.6, 95% CI 1.2–6.6, p = 0.042), and absence of ILD (OR 0.1, 95% CI 0.01–0.9, p = 0.040)
