Fibromyalgia: from pathophysiology to therapy

Nature Reviews Rheumatology , 07/21/2011

Schmidt–Wilcke T et al. – The roles of biological and psychological stress, genetic factors, and pain and sensory processing in the pathophysiology of fibromyalgia and related conditions are discussed. In addition, pharmacological treatments, including monoamine modulators, calcium channel modulators and gamma–aminobutyric acid modulators, as well as nonpharmacological treatment options are considered.

  • Individuals with fibromyalgia generally experience chronic widespread pain, which can be accompanied by further symptoms including fatigue, sleep disturbances, cognitive dysfunction, anxiety and depressive episodes.
  • As the recognition and diagnosis of fibromyalgia has improved, the availability of therapeutic options for patients has increased.
  • Furthermore, research into the neurobiological mechanisms that contribute to the chronic pain and concomitant symptoms experienced by patients with fibromyalgia has advanced the understanding of this debilitating disorder.

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