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Rheumatology - Systemic Lupus (SLE) News & Articles
What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content
- Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
- MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Rheumatology
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Articles
Latest (1) Full Text Articles (15) Focus on Osteoporosis981 Brain Hypoperfusion in a Girl With Systemic Lupus Erythematosus Pediatric Neurology , October 18, 2011
982 Neutrophils in the pathogenesis and manifestations of SLE Nature Reviews Rheumatology , October 17, 2011
983 Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus Clinical Rheumatology, October 14, 2011
984 Serum IgG levels demonstrate seasonal change in connective tissue diseases: a large-scale, 4-year analysis in Japanese Modern Rheumatology, October 14, 2011
985 Enhanced CCR5+/CCR3+ T helper cell ratio in patients with active cutaneous lupus erythematosus Lupus, October 14, 2011
986 Cyclic adenosine 5'-monophosphate response element modulator alpha suppresses spleen tyrosine kinase expression in normal but not in SLE T cells Arthritis & Rheumatism, October 13, 2011
987 Acute cerebellar ataxia in lupus Lupus, October 13, 2011
988 Intravitreal bevacizumab for severe vaso-occlusive retinopathy in systemic lupus erythematosus Rheumatology International, October 12, 2011
989 High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus Journal of Internal Medicine, October 12, 2011
990 Expression of human tumor necrosis factor-like weak inducer of apoptosis in patients with systemic lupus erythematosus Clinical Rheumatology, October 11, 2011
991 Increased levels of BAFF in patients with systemic lupus erythematosus are associated with acute-phase reactants, independent of BAFF genetics: A case–control study Rheumatology, October 11, 2011
992 The Patient Reported Outcomes in Lupus (PATROL) study: role of depression in health-related quality of life in a Southern California lupus cohort Lupus, October 11, 2011
993 Intestinal pseudo-obstruction syndrome in systemic lupus erythematosus Lupus, October 11, 2011
994 IRF5 activation in monocytes of SLE patients is triggered by circulating autoantigens independent of type I IFN Arthritis & Rheumatism, October 11, 2011
995 Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers Lupus, October 10, 2011
996 Implications of immunosuppressive agents in cardiovascular risks and carotid intima media thickness among lupus nephritis patients Lupus, October 10, 2011
997 Complement and antibody primary immunodeficiency in juvenile systemic lupus erythematosus patients Lupus, October 10, 2011
998 Preferential transmission of genetic risk variants of candidate loci at 6p21 from asymptomatic grandparents to mothers of children with neonatal lupus Arthritis & Rheumatism, October 7, 2011
999 Possible role of the JAK/STAT pathways in the regulation of T cell-interferon related genes in systemic lupus erythematosus Lupus, October 7, 2011
1000 Oxidative stress is associated with liver damage, inflammatory status, and corticosteroid therapy in patients with systemic lupus erythematosus Lupus, October 7, 2011
Clinical Pearls in Rheumatology
- Independent predictors of disease activity in patients with systemic lupus include age, renal activity, immunosuppressant use and pre-existing organ damage
- When treating rheumatoid arthritis (RA), male sex, short duration of symptoms and less tender joints at baseline were found to be independent predictors of sustained remission with conventional DMARDs
- Higher baseline DAS28 scores and positive rheumatoid factor status are significantly associated with an improvement in response to rituximab treatment
Highlights in Rheumatology
ACPA correlate with disease progression in JIA
In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.
Read the article summaryPredicting cardiovascular mortality in SLE
In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.
Read the article summaryAnti-apoA-1 antibodies predict cardiovascular disease in RA patients
In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.
Read the article summaryMost Popular Rheumatology Articles
Last month's top read Top Articles of 20121 Vitamin D in SLE: Modest association with disease activity and urine protein/creatinine ratio Arthritis & Rheumatism, April 2, 2013
2 Depression with psychotic features in a child with SLE: successful therapy with psychotropic medications--case report European Child and Adolescent Psychiatry, April 3, 2013
3 The Early Protective Effect of Hydroxychloroquine on the Risk of Cumulative Damage in Patients with Systemic Lupus Erythematosus The Journal of Rheumatology, April 18, 2013
4 New therapeutics in systemic lupus erythematosus Current Opinion in Rheumatology, April 1, 2013
5 Therapeutic potential of SIGIRR in systemic lupus erythematosus Rheumatology International, April 4, 2013
6 Review of refractory lupus nephritis International Journal of Clinical Rheumatology, April 2, 2013 Review Article
7 Predicting Sjogrens syndrome in patients with recent-onset SLE Rheumatology, April 19, 2013
8 Is there a difference in systemic lupus erythematosus with and without Raynauds phenomenon Rheumatology International, April 11, 2013 Clinical Guideline
9 Maternal and neonatal outcomes in pregnancies complicated by systemic lupus erythematosus: a population-based study Journal of Obstetrics and Gynaecology Canada, April 15, 2013 Free full text
10 Exacerbation of latent lupus: is the culprit acid-fast bacilli or antitubercular therapy Clinical Rheumatology, April 10, 2013
11 Corticosteroid-induced neuropsychiatric disorders: review and contrast with neuropsychiatric lupus Rheumatology International, April 17, 2013
12 Improvements in health-related quality of life with belimumab, a B-lymphocyte stimulator-specific inhibitor, in patients with autoantibody-positive systemic lupus erythematosus from the randomised controlled BLISS trials Annals of Rheumatic Diseases, April 9, 2013
13 Malignancies in systemic lupus erythematosus International Journal of Clinical Rheumatology, April 16, 2013 Review Article
14 Stress as a trigger of disease flares in SLE Rheumatology International, April 23, 2013
15 Immunogenicity and safety of a quadrivalent human papillomavirus vaccine in patients with systemic lupus erythematosus: a case-control study Annals of Rheumatic Diseases, April 8, 2013
16 Cumulative Burden of Oral Corticosteroid Adverse Effects and the Economic Implications of Corticosteroid Use in Patients With Systemic Lupus Erythematosus Clinical Therapeutics, April 29, 2013
17 Immune Complex Disease With a Lupus-like Pattern of Deposition in an Antinuclear Antibody-Negative Patient American Journal of Kidney Diseases, April 5, 2013
18 Anti B-cell therapy against refractory thrombocytopenia in SLE and MCTD patients: long-term follow-up and review of the literature Lupus, April 25, 2013
19 Late-onset systemic lupus erythematosus: clinical features, course, and prognosis Clinical Rheumatology, March 26, 2013
20 Efficacy and safety of epratuzumab in patients with moderate/severe flaring systemic lupus erythematosus: results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up Rheumatology, April 1, 2013
Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatology more
Other Topics in Rheumatology
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