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Rheumatology - Systemic Lupus (SLE) News & Articles
What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content
- Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
- MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Rheumatology
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Articles
Latest (1) Full Text Articles (15) Focus on Osteoarthritis541 Inflammation associated anemia and ferritin as disease markers in systemic lupus erythematosus Full Text Arthritis Research & Therapy, August 9, 2012 Clinical Article
542 Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis Annals of Rheumatic Diseases, August 9, 2012 Clinical Article
543 Platelets: active players in the pathogenesis of arthritis and SLE Nature Reviews Rheumatology , August 9, 2012 Clinical Article
544 Hydroxychloroquine Use Is Associated with Lower Odds of Persistently Positive Antiphospholipid Antibodies and/or Lupus Anticoagulant in Systemic Lupus Erythematosus The Journal of Rheumatology, August 7, 2012 Clinical Article
545 Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis Modern Rheumatology, August 7, 2012 Evidence Based Medicine
546 Altered expression of TNFSF4 and TRAF2 mRNAs in peripheral blood mononuclear cells in patients with systemic lupus erythematosus: association with atherosclerotic symptoms and lupus nephritis Inflammation Research, August 7, 2012
547 Response to ustekinumab in a patient with both severe psoriasis and hypertrophic cutaneous lupus Lupus, August 7, 2012 Clinical Article
548 Increased Risk of Systemic Lupus Erythematosus in 29,000 Patients with Biopsy-verified Celiac Disease The Journal of Rheumatology, August 6, 2012 Clinical Article
549 New insights into mechanisms of therapeutic effects of antimalarial agents in SLE Nature Reviews Rheumatology , August 2, 2012 Clinical Article
550 Prevalence, incidence, and demographics of systemic lupus erythematosus and lupus nephritis from 2000 to 2004 among children in the US medicaid beneficiary population Arthritis & Rheumatism, August 1, 2012
551 Safety and pharmacodynamic results of rontalizumab in a phase i, placebo controlled, double blind, dose escalation study in systemic lupus erythematosus Arthritis & Rheumatism, July 31, 2012 Clinical Article
552 The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes Annals of Rheumatic Diseases, July 30, 2012
553 Autoantibody profiling to follow evolution of lupus syndromes Full Text Arthritis Research & Therapy, July 30, 2012
554 Abatacept for lupus nephritis: Alternative definitions of complete response support conflicting conclusions Arthritis & Rheumatism, July 27, 2012 Clinical Article
555 Two independent functional risk haplotypes in TNIP1 are associated with systemic lupus erythematosus Arthritis & Rheumatism, July 27, 2012
556 Type I IFN system in the development and manifestations of SLE Current Opinion in Rheumatology, July 27, 2012
557 LupusQoL-FR is valid to assess quality of life in patients with systemic lupus erythematosus Rheumatology, July 26, 2012
558 Cognitive Impairment in Systemic Lupus Erythematosus Women with Elevated Autoantibodies and Normal Single Photon Emission Computerized Tomography Psychotherapy and Psychosomatics, July 25, 2012
559 Successful tocilizumab and tacrolimus treatment in a patient with rheumatoid arthritis complicated by systemic lupus erythematosus Lupus, July 25, 2012
560 Patient self-report RADAI joint counts on a MDHAQ are informative in a cohort of consecutive patients with rheumatic diseases other than RA seen in usual care Arthritis Care & Research , July 25, 2012
Clinical Pearls in Rheumatology
- Independent predictors of disease activity in patients with systemic lupus include age, renal activity, immunosuppressant use and pre-existing organ damage
- When treating rheumatoid arthritis (RA), male sex, short duration of symptoms and less tender joints at baseline were found to be independent predictors of sustained remission with conventional DMARDs
- Higher baseline DAS28 scores and positive rheumatoid factor status are significantly associated with an improvement in response to rituximab treatment
Highlights in Rheumatology
ACPA correlate with disease progression in JIA
In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.
Read the article summaryPredicting cardiovascular mortality in SLE
In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.
Read the article summaryAnti-apoA-1 antibodies predict cardiovascular disease in RA patients
In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.
Read the article summaryMost Popular Rheumatology Articles
Last month's top read Top Articles of 20121 Vitamin D in SLE: Modest association with disease activity and urine protein/creatinine ratio Arthritis & Rheumatism, April 2, 2013
2 Depression with psychotic features in a child with SLE: successful therapy with psychotropic medications--case report European Child and Adolescent Psychiatry, April 3, 2013
3 The Early Protective Effect of Hydroxychloroquine on the Risk of Cumulative Damage in Patients with Systemic Lupus Erythematosus The Journal of Rheumatology, April 18, 2013
4 New therapeutics in systemic lupus erythematosus Current Opinion in Rheumatology, April 1, 2013
5 Therapeutic potential of SIGIRR in systemic lupus erythematosus Rheumatology International, April 4, 2013
6 Review of refractory lupus nephritis International Journal of Clinical Rheumatology, April 2, 2013 Review Article
7 Predicting Sjogrens syndrome in patients with recent-onset SLE Rheumatology, April 19, 2013
8 Is there a difference in systemic lupus erythematosus with and without Raynauds phenomenon Rheumatology International, April 11, 2013 Clinical Guideline
9 Maternal and neonatal outcomes in pregnancies complicated by systemic lupus erythematosus: a population-based study Journal of Obstetrics and Gynaecology Canada, April 15, 2013 Free full text
10 Exacerbation of latent lupus: is the culprit acid-fast bacilli or antitubercular therapy Clinical Rheumatology, April 10, 2013
11 Corticosteroid-induced neuropsychiatric disorders: review and contrast with neuropsychiatric lupus Rheumatology International, April 17, 2013
12 Improvements in health-related quality of life with belimumab, a B-lymphocyte stimulator-specific inhibitor, in patients with autoantibody-positive systemic lupus erythematosus from the randomised controlled BLISS trials Annals of Rheumatic Diseases, April 9, 2013
13 Malignancies in systemic lupus erythematosus International Journal of Clinical Rheumatology, April 16, 2013 Review Article
14 Stress as a trigger of disease flares in SLE Rheumatology International, April 23, 2013
15 Immunogenicity and safety of a quadrivalent human papillomavirus vaccine in patients with systemic lupus erythematosus: a case-control study Annals of Rheumatic Diseases, April 8, 2013
16 Cumulative Burden of Oral Corticosteroid Adverse Effects and the Economic Implications of Corticosteroid Use in Patients With Systemic Lupus Erythematosus Clinical Therapeutics, April 29, 2013
17 Immune Complex Disease With a Lupus-like Pattern of Deposition in an Antinuclear Antibody-Negative Patient American Journal of Kidney Diseases, April 5, 2013
18 Anti B-cell therapy against refractory thrombocytopenia in SLE and MCTD patients: long-term follow-up and review of the literature Lupus, April 25, 2013
19 Late-onset systemic lupus erythematosus: clinical features, course, and prognosis Clinical Rheumatology, March 26, 2013
20 Efficacy and safety of epratuzumab in patients with moderate/severe flaring systemic lupus erythematosus: results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up Rheumatology, April 1, 2013
Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatology more
Other Topics in Rheumatology
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