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Rheumatology - Systemic Lupus (SLE) News & Articles
What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content
- Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
- MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Rheumatology
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Articles
Latest (1) Full Text Articles (15) Focus on Osteoarthritis421 An update on cross-cultural adaptation of US English SMILEY Lupus, October 24, 2012
422 Clinicopathological characteristics and outcomes of male lupus nephritis in China Lupus, October 24, 2012
423 Belimumab: targeted therapy for lupus International Journal of Rheumatic Diseases, October 23, 2012 Clinical Article
424 Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation Full Text Arthritis Research & Therapy, October 18, 2012
425 Markers of acute neuropsychiatric systemic lupus erythematosus: a multidisciplinary evaluation Rheumatology International, October 17, 2012 Clinical Article
426 MicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis Nature Reviews Rheumatology , October 17, 2012 Clinical Article
427 Ambulatory blood pressure and subclinical cardiovascular disease in patients with juvenile-onset systemic lupus erythematosus Pediatric Nephrology, October 17, 2012 Clinical Article
428 Updated analysis of standardised photoprovocation in patients with cutaneous lupus erythematosus Arthritis Care & Research , October 17, 2012
429 Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus Bone Marrow Transplantation, October 17, 2012
430 Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity Full Text Arthritis Research & Therapy, October 16, 2012 Clinical Article
431 Successful treatment of rectal ulcers in a patient with systemic lupus erythematosus using corticosteroids and tacrolimus Modern Rheumatology, October 16, 2012
432 Anti-NR2 glutamate receptor auto-IgG antibodies from patients with systemic lupus erythematosus activate endothelial cells Arthritis & Rheumatism, October 12, 2012
433 Intestinal Vasculitis and Renal Infarction in a Lupus Patient With Antiphospholipid Syndrome JCR: Journal of Clinical Rheumatology, October 12, 2012
434 Type B insulin resistance syndrome induced by systemic lupus erythematosus and successfully treated with intravenous immunoglobulin: case report and systematic review Clinical Rheumatology, October 11, 2012 Evidence Based Medicine
435 Anti-mullerian hormone and ovarian reserve in systemic lupus erythematosus Arthritis & Rheumatism, October 10, 2012
436 Beyond the LUNAR trial. Efficacy of rituximab in refractory lupus nephritis Nephrology Dialysis Transplantation, October 10, 2012
437 Complete remission in severe lupus nephritis: assessing the rate of loss in proteinuria Nephrology Dialysis Transplantation, October 10, 2012
438 Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort Annals of Rheumatic Diseases, October 9, 2012 Clinical Article
439 Six-year follow-up study of bone mineral density in patients with systemic lupus erythematosus Osteoporosis International, October 9, 2012 Clinical Article
440 Systemic Lupus Erythematosus Presenting with Status Epilepticus: A Case Report Turkish Journal of Rheumatology, October 8, 2012
Clinical Pearls in Rheumatology
- Independent predictors of disease activity in patients with systemic lupus include age, renal activity, immunosuppressant use and pre-existing organ damage
- When treating rheumatoid arthritis (RA), male sex, short duration of symptoms and less tender joints at baseline were found to be independent predictors of sustained remission with conventional DMARDs
- Higher baseline DAS28 scores and positive rheumatoid factor status are significantly associated with an improvement in response to rituximab treatment
Highlights in Rheumatology
ACPA correlate with disease progression in JIA
In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.
Read the article summaryPredicting cardiovascular mortality in SLE
In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.
Read the article summaryAnti-apoA-1 antibodies predict cardiovascular disease in RA patients
In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.
Read the article summaryMost Popular Rheumatology Articles
Last month's top read Top Articles of 20121 Vitamin D in SLE: Modest association with disease activity and urine protein/creatinine ratio Arthritis & Rheumatism, April 2, 2013
2 Depression with psychotic features in a child with SLE: successful therapy with psychotropic medications--case report European Child and Adolescent Psychiatry, April 3, 2013
3 The Early Protective Effect of Hydroxychloroquine on the Risk of Cumulative Damage in Patients with Systemic Lupus Erythematosus The Journal of Rheumatology, April 18, 2013
4 New therapeutics in systemic lupus erythematosus Current Opinion in Rheumatology, April 1, 2013
5 Therapeutic potential of SIGIRR in systemic lupus erythematosus Rheumatology International, April 4, 2013
6 Review of refractory lupus nephritis International Journal of Clinical Rheumatology, April 2, 2013 Review Article
7 Predicting Sjogrens syndrome in patients with recent-onset SLE Rheumatology, April 19, 2013
8 Is there a difference in systemic lupus erythematosus with and without Raynauds phenomenon Rheumatology International, April 11, 2013 Clinical Guideline
9 Maternal and neonatal outcomes in pregnancies complicated by systemic lupus erythematosus: a population-based study Journal of Obstetrics and Gynaecology Canada, April 15, 2013 Free full text
10 Exacerbation of latent lupus: is the culprit acid-fast bacilli or antitubercular therapy Clinical Rheumatology, April 10, 2013
11 Corticosteroid-induced neuropsychiatric disorders: review and contrast with neuropsychiatric lupus Rheumatology International, April 17, 2013
12 Improvements in health-related quality of life with belimumab, a B-lymphocyte stimulator-specific inhibitor, in patients with autoantibody-positive systemic lupus erythematosus from the randomised controlled BLISS trials Annals of Rheumatic Diseases, April 9, 2013
13 Malignancies in systemic lupus erythematosus International Journal of Clinical Rheumatology, April 16, 2013 Review Article
14 Stress as a trigger of disease flares in SLE Rheumatology International, April 23, 2013
15 Immunogenicity and safety of a quadrivalent human papillomavirus vaccine in patients with systemic lupus erythematosus: a case-control study Annals of Rheumatic Diseases, April 8, 2013
16 Cumulative Burden of Oral Corticosteroid Adverse Effects and the Economic Implications of Corticosteroid Use in Patients With Systemic Lupus Erythematosus Clinical Therapeutics, April 29, 2013
17 Immune Complex Disease With a Lupus-like Pattern of Deposition in an Antinuclear Antibody-Negative Patient American Journal of Kidney Diseases, April 5, 2013
18 Anti B-cell therapy against refractory thrombocytopenia in SLE and MCTD patients: long-term follow-up and review of the literature Lupus, April 25, 2013
19 Late-onset systemic lupus erythematosus: clinical features, course, and prognosis Clinical Rheumatology, March 26, 2013
20 Efficacy and safety of epratuzumab in patients with moderate/severe flaring systemic lupus erythematosus: results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up Rheumatology, April 1, 2013
Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatology more
Other Topics in Rheumatology
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