What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content
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1 Adherence to raloxifene therapy: assessment methods and relationship with efficacy Osteoporosis International, May 24, 2013 Clinical Article
2 Monotherapy with tocilizumab or TNF-alpha inhibitors in patients with rheumatoid arthritis: efficacy, treatment satisfaction, and persistence in routine clinical practice Clinical Rheumatology, May 24, 2013 Clinical Article
3 Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment. Post hoc analyses from the CIMESTRA trial Annals of Rheumatic Diseases, May 23, 2013 Clinical Article
4 Using actigraphy to measure sleep patterns in rheumatoid arthritis: A pilot study in patients taking night-time prednisone Musculoskeletal Care, May 23, 2013 Clinical Article
5 Steroid injection for inferior heel pain: a randomised controlled trial Annals of Rheumatic Diseases, May 22, 2013 Clinical Article
6 Efficacy of oral prednisolone in active ankylosing spondylitis: results of a double-blind, randomised, placebo-controlled short-term trial Annals of Rheumatic Diseases, May 22, 2013 Clinical Article
7 Infliximab for 6 months added on combination therapy in early rheumatoid arthritis: 2-year results from an investigator-initiated, randomised, double-blind, placebo-controlled study (the NEO-RACo Study) Annals of Rheumatic Diseases, May 22, 2013 Clinical Article
8 Similar response rates in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis after 1 year of treatment with etanercept: results from the ESTHER trial Annals of Rheumatic Diseases, May 22, 2013 Clinical Article
9 A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study Annals of Rheumatic Diseases, May 22, 2013 Clinical Article
10 Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study Annals of Rheumatic Diseases, May 22, 2013 Clinical Article
11 Methotrexate polyglutamation in relation to infliximab pharmacokinetics in rheumatoid arthritis Annals of Rheumatic Diseases, May 22, 2013 Clinical Article
12 Efficacy of rituximab in systemic manifestations of primary Sjogrens syndrome: results in 78 patients of the AutoImmune and Rituximab registry Annals of Rheumatic Diseases, May 22, 2013 Clinical Article
13 Difference in the risk of serious infections in patients with rheumatoid arthritis treated with adalimumab, infliximab and etanercept: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry Annals of Rheumatic Diseases, May 22, 2013 Clinical Article
14 Efficacy and safety of adalimumab in patients with non-radiographic axial spondyloarthritis: results of a randomised placebo-controlled trial (ABILITY-1) Annals of Rheumatic Diseases, May 21, 2013 Clinical Article
15 A randomised, double-blind, parallel-group study to demonstrate equivalence in efficacy and safety of CT-P13 compared with innovator infliximab when coadministered with methotrexate in patients with active rheumatoid arthritis: the PLANETRA study Annals of Rheumatic Diseases, May 21, 2013 Clinical Article
16 Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study Annals of Rheumatic Diseases, May 21, 2013 Clinical Article
17 Juvenile idiopathic arthritis: an update on current pharmacotherapy and future perspectives Expert Opinion on Pharmacotherapy, May 21, 2013 Clinical Article
18 Behcet Disease-associated Uveitis Successfully Treated with Golimumab Ocular Immunology and Inflammation, May 21, 2013 Clinical Article
19 Efficacy of ketoprofen vs. ibuprofen and diclofenac: a systematic review of the literature and meta-analysis Clinical and Experimental Rheumatology Online, May 20, 2013 Evidence Based Medicine Review Article Clinical Article
20 Validation of methotrexate-first strategy in early poor prognosis rheumatoid arthritis: Results from a randomized, double-blind, 2-year trial Arthritis & Rheumatism, May 20, 2013 Clinical Article
In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.
Read the article summaryIn a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.
Read the article summaryIn a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.
Read the article summary1 Osteoarthritis guidelines: a progressive role for topical nonsteroidal anti-inflammatory drugs Journal of Multidisciplinary Healthcare, April 5, 2013 Review Article Clinical Guideline
2 Statin Use in Giant Cell Arteritis: A Retrospective Study The Journal of Rheumatology, April 3, 2013
3
Simvastatin inhibits the pro-inflammatory and pro-thrombotic effects of IL-17 and TNF-α on endothelial cells
Annals of Rheumatic Diseases, April 10, 2013
Exclusive Author Commentary
4 Efficacy and safety of epratuzumab in patients with moderate/severe flaring systemic lupus erythematosus: results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up Rheumatology, April 1, 2013
5 Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial Annals of Rheumatic Diseases, April 8, 2013
6 Antibiotics for Treatment of Reactive Arthritis: A Systematic Review and Metaanalysis The Journal of Rheumatology, April 18, 2013 Evidence Based Medicine Review Article
7 Sifalimumab, a human anti-interferon-a monoclonal antibody, in systemic lupus erythematosus: A phase 1 randomized controlled, dose-escalation study Arthritis & Rheumatism, February 13, 2013
8 Diclofenac in the treatment of osteoarthritis International Journal of Clinical Rheumatology, April 2, 2013
9 Profile of certolizumab and its potential in the treatment of psoriatic arthritis Drug Design, Development and Therapy, April 25, 2013 Free full text
10 Using cyclophosphamide in inflammatory rheumatic diseases European Journal of Internal Medicine , March 29, 2013 Review Article
11 Rationale for treating primary Sjogrens syndrome patients with an anti-CD6 monoclonal antibody (Itolizumab) Immunologic Research, April 26, 2013 Review Article
12
Is there a place for cyclophosphamide in the treatment of giant-cell arteritis? A case series and systematic review
Seminars in Arthritis and Rheumatism, March 5, 2013
Evidence Based Medicine
Exclusive Author Commentary
13 A phase 2 dose-ranging study of subcutaneous tabalumab for the treatment of patients with active rheumatoid arthritis and an inadequate response to methotrexate Annals of Rheumatic Diseases, April 22, 2013
14 Biologic disease-modifying anti-rheumatic drugs and the risk of non-vertebral osteoporotic fractures in patients with rheumatoid arthritis aged 50 years and over Osteoporosis International, March 20, 2013
15 Cumulative Burden of Oral Corticosteroid Adverse Effects and the Economic Implications of Corticosteroid Use in Patients With Systemic Lupus Erythematosus Clinical Therapeutics, April 29, 2013
16 A Comparison of the Efficacy of Dry Needling, Lidocaine Injection, and Oral Flurbiprofen Treatments in Patients with Myofascial Pain Syndrome: A Double-Blind (For Injection, Groups Only), Randomized Clinical Trial Turkish Journal of Rheumatology, March 21, 2013 Free full text
17 Longterm Effects of Rituximab on B Cell Counts and Autoantibody Production in Rheumatoid Arthritis: Use of High-sensitivity Flow Cytometry for More Sensitive Assessment of B Cell Depletion The Journal of Rheumatology, April 15, 2013
18 Tanezumab reduces osteoarthritic hip pain: Results of a randomized, double-blind, placebo-controlled phase 3 trial Arthritis & Rheumatism, April 2, 2013
19 Switching between TNF inhibitors in psoriatic arthritis: data from the NOR-DMARD study Annals of Rheumatic Diseases, April 11, 2013
20 Chronic Opioid Use in Fibromyalgia Syndrome: A Clinical Review JCR: Journal of Clinical Rheumatology, February 25, 2013 Review Article
Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatology more
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