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Rheumatology - Bone Metabolism News & Articles
What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content
- Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
- MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Rheumatology
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Articles
Latest (3) Full Text Articles (73) Focus on Osteoporosis861 Corticosteroid use and bone mineral accretion in children with asthma: Effect modification by vitamin D The Journal of Allergy and Clinical Immunology, May 21, 2012 Clinical Article
862 Osteocyte Apoptosis and Lipid Infiltration as Mechanisms of Alcohol-Induced Bone Loss Alcohol and Alcoholism , May 21, 2012
863 A cohort study of osteoporosis health knowledge and medication use in older adults with minimal trauma fracture Archives of Osteoporosis, May 18, 2012 Clinical Article
864 Does frequency of resistance training affect tibial cortical bone density in older women? A randomized controlled trial Osteoporosis International, May 18, 2012
865 Mitochondrial DNA Copy Number in Peripheral Blood Is Associated with Femoral Neck Bone Mineral Density in Postmenopausal Women The Journal of Rheumatology, May 18, 2012
866 Significant inverse relationship between serum undercarboxylated osteocalcin and glycemic control in maintenance hemodialysis patients Osteoporosis International, May 18, 2012
867 Are long-term bisphosphonate users a reality? Dose years for current bisphosphonate users assessed using the danish national prescription database Osteoporosis International, May 18, 2012
868 Alendronate in patients with calcium nephrolithiasis and loss of bone mass Central European Journal of Medicine, May 17, 2012 Clinical Article
869 Phosphate homeostasis and its role in bone health Pediatric Nephrology, May 17, 2012
870 High Circulating Sclerostin is Present in Patients with Thalassemia-associated Osteoporosis and Correlates with Bone Mineral Density Hormone and Metabolic Research, May 17, 2012
871 Determinants of bone mineral density in stable kidney transplant recipients Journal of Nephrology, May 16, 2012
872 The association of bone mineral density and parathyroid hormone with serum magnesium in adult patients with sickle-cell anaemia Archives of Medical Science, May 16, 2012
873 Impaired bone mineralization accompanied by low vitamin D and secondary hyperparathyroidism in patients with femoral neck fracture Osteoporosis International, May 15, 2012
874 Estimating the excess costs for patients with incident fractures, prevalent fractures, and nonfracture osteoporosis Osteoporosis International, May 15, 2012
875 Hip fracture patients in India have vitamin D deficiency and secondary hyperparathyroidism Osteoporosis International, May 15, 2012
876 Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity Journal of Clinical Oncology, May 14, 2012 Clinical Article
877 Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment Full Text Arthritis Research & Therapy, May 11, 2012
878 Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis: results from a phase 2, randomized, parallel-arm, open-label study British Journal of Haematology, May 11, 2012 Clinical Article
879 Health-related predictors of falls and fractures in women over 40 Osteoporosis International, May 11, 2012
880 Fracture rate in patients with myasthenia gravis: the general practice research database Osteoporosis International, May 11, 2012
Clinical Pearls in Rheumatology
- Independent predictors of disease activity in patients with systemic lupus include age, renal activity, immunosuppressant use and pre-existing organ damage
- When treating rheumatoid arthritis (RA), male sex, short duration of symptoms and less tender joints at baseline were found to be independent predictors of sustained remission with conventional DMARDs
- Higher baseline DAS28 scores and positive rheumatoid factor status are significantly associated with an improvement in response to rituximab treatment
Highlights in Rheumatology
ACPA correlate with disease progression in JIA
In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.
Read the article summaryPredicting cardiovascular mortality in SLE
In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.
Read the article summaryAnti-apoA-1 antibodies predict cardiovascular disease in RA patients
In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.
Read the article summaryMost Popular Rheumatology Articles
Last month's top read Top Articles of 20121 Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) Current Medical Research and Opinion, April 3, 2013
2 Persistence with osteoporosis medication among newly-treated osteoporotic patients Journal of Bone and Mineral Metabolism, April 12, 2013 Review Article
3 Eldecalcitol: newly developed active vitamin D3 analog for the treatment of osteoporosis Expert Opinion on Pharmacotherapy, April 9, 2013
4 The Efficacy and Safety of Bisphosphonates for Osteoporosis or Osteopenia in Crohns Disease: A Meta-Analysis Digestive Diseases and Sciences, April 22, 2013 Evidence Based Medicine
5 Relationship of bone mineral density to progression of knee osteoarthritis Arthritis & Rheumatism, April 4, 2013
6 Vitamin K: Novel molecular mechanisms of action and its roles in osteoporosis Geriatrics and Gerontology International, March 29, 2013
7 Opportunistic Screening for Osteoporosis Using Abdominal Computed Tomography Scans Obtained for Other Indications Annals of Internal Medicine, April 17, 2013
8 Serum osteocalcin levels are inversely associated with abdominal aortic calcification in men with type 2 diabetes mellitus Osteoporosis International, April 8, 2013 Review Article
9 Systemic lupus erythematosus is associated with a higher risk of cervical but not trochanteric hip fracture: A nationwide population-based study Arthritis Care & Research , April 18, 2013
10 Teriparatide for Idiopathic Osteoporosis in Premenopausal Women: A Pilot Study Journal of Clinical Endocrinology and Metabolism, April 5, 2013
11 Influence of recency and duration of glucocorticoid use on bone mineral density and risk of fractures: population-based cohort study Osteoporosis International, April 15, 2013
12 Osteoporosis treatment European Journal of Internal Medicine , April 25, 2013
13 Biologic therapies and systemic bone loss in Rheumatoid Arthritis Autoimmunity Reviews, April 5, 2013
14 Development and validation of a new radiographic scoring system to evaluate bone and cartilage destruction and healing of large joints with rheumatoid arthritis: ARASHI (Assessment of rheumatoid arthritis by scoring of large joint destruction and healing in radiographic imaging) study Modern Rheumatology, April 29, 2013
15 Assessment of OPG/RANK/RANKL Gene Expression Levels in Peripheral Blood Mononuclear Cells (PBMC) After Treatment With Strontium Ranelate and Ibandronate in Patients With Postmenopausal Osteoporosis Journal of Clinical Endocrinology and Metabolism, April 2, 2013 Review Article
16 Causes, mechanisms and management of paediatric osteoporosis Nature Reviews Rheumatology , April 19, 2013
17 Vitamin D deficiency and its relation to bone mineral density and liver fibrosis in HIV–HCV coinfection Antiviral Therapy , April 1, 2013
18 Continuous long-term anti-TNF therapy does not lead to an increase in the rate of new bone formation over 8 years in patients with ankylosing spondylitis Annals of Rheumatic Diseases, April 10, 2013
19 The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation: may estrogen be a magic bullet? Menopause International, April 11, 2013
20 A rapid, novel method of volumetric assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis Osteoarthritis and Cartilage , April 23, 2013
Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatology more
Other Topics in Rheumatology
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