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Rheumatology - Autoimmune/Heritable News & Articles

What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content

  • Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
  • MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

Your Unread Messages in Rheumatology

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Articles

Latest (2) Full Text Articles (22) Focus on Gout
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

1 Potential role of human-specific genes, human-specific microRNAs and human-specific non-coding regulatory RNAs in the pathogenesis of Systemic Sclerosis and Sjogren’s Syndrome Autoimmunity Reviews, May 17, 2013    Clinical Article

2 Case of diffuse cutaneous systemic sclerosis with anti-Ku and anti-centromere antibodies The Journal of Dermatology, May 17, 2013

Prior Articles

3 Systemic Sclerosis in Canada's North American Native Population: Assessment of Clinical and Serological Manifestations The Journal of Rheumatology, May 16, 2013    Clinical Article

4 Systemic sclerosis patients with and without pulmonary arterial hypertension: a nailfold capillaroscopy study Rheumatology, May 15, 2013    Clinical Article

5 Targeting inflammasomes in rheumatic diseases Nature Reviews Rheumatology , May 15, 2013    Review Article

6 Anti-CADM-140/MDA5 autoantibody titer correlates with disease activity and predicts disease outcome in patients with dermatomyositis and rapidly progressive interstitial lung disease Modern Rheumatology, May 15, 2013    Clinical Article

7 Interleukin-7 and its receptor: The axis of evil to target in Sjogrens syndrome Arthritis & Rheumatism, May 14, 2013    Review Article

8 Differences in clinical manifestations, treatment, and concordance rates with two major sets of criteria for Behcets syndrome for patients in the US and Japan: data from a large, three-center cohort study Modern Rheumatology, May 14, 2013    Clinical Article

9 Serum level of APRIL/BLyS in Behcets disease patients: clinical significance in uveitis and disease activity Modern Rheumatology, May 14, 2013    Clinical Article

10 Systemic sclerosis sine scleroderma: distinct features in a large Brazilian cohort Rheumatology, May 14, 2013    Clinical Article

11 Four-year-olds, healthy or recovering from Juvenile Dermatomyositis, do not achieve a full score on the Childhood Myositis Assessment Scale (CMAS) Arthritis Care & Research , May 14, 2013    Clinical Article

12 Mortality factors in idiopathic inflammatory myopathy: focusing on malignancy and interstitial lung disease Modern Rheumatology, May 14, 2013    Review Article    Clinical Article

13 Dnase1l3 mutations in hypocomplementemic urticarial vasculitis syndrome Arthritis & Rheumatism, May 14, 2013    Review Article

14 A case of Epstein-Barr virus-related lymphadenopathy mimicking the clinical features of IgG4-related disease Modern Rheumatology, May 14, 2013

15 Location of CD4+ T Cell Priming Regulates the Differentiation of Th1 and Th17 Cells and Their Contribution to Arthritis The Journal of Immunology, May 13, 2013    Review Article

16 Clinical features distinguishing lymphoma development in primary Sjogrens syndrome--A retrospective cohort study Seminars in Arthritis and Rheumatism, May 10, 2013    Clinical Article

17 Evaluation of a mail-delivered, print-format, self-management program for persons with systemic sclerosis Clinical Rheumatology, May 10, 2013    Clinical Article

18 Ultraviolet radiation exposure is associated with clinical and autoantibody phenotypes in Juvenile Myositis Arthritis & Rheumatism, May 10, 2013    Review Article

19 Neuropsychiatric Lupus: Classification Criteria in Neuroimaging Studies The Canadian Journal of Neurological Sciences, May 9, 2013    Evidence Based Medicine    Review Article

20 Leprosy in a rheumatology setting: a challenging mimic to expose Clinical Rheumatology, May 9, 2013    Clinical Article

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Clinical Pearls in Rheumatology

Highlights in Rheumatology

ACPA correlate with disease progression in JIA

In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.

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Predicting cardiovascular mortality in SLE

In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.

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Anti-apoA-1 antibodies predict cardiovascular disease in RA patients

In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.

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Most Popular Rheumatology Articles

Last month's top read Top Articles of 2012

1 Targeted therapies for systemic sclerosis Nature Reviews Rheumatology , April 10, 2013

2 Current diagnostic tools for Sjogrens syndrome International Journal of Clinical Rheumatology, April 3, 2013

3 Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis Arthritis Research & Therapy, April 22, 2013

4 Antiphospholipid antibodies in children with systemic lupus erythematosus: a long-term clinical and laboratory follow-up status study from northwest India Rheumatology International, April 8, 2013

5 Skin and Mucosa Care in Systemic Sclerosis - Patients' and Family Caregivers' Experiences and Expectations of a Specific Education Programme: A Qualitative Study Musculoskeletal Care, March 28, 2013

6 The enhanced liver fibrosis test: a clinical grade, validated serum test, biomarker of overall fibrosis in systemic sclerosis Annals of Rheumatic Diseases, March 25, 2013

7 A meta-analysis of healing and prevention of digital ulcers (DU) in systemic sclerosis (SSc) Arthritis Care & Research , April 2, 2013    Evidence Based Medicine

8 Risk factors for body composition abnormalities in systemic sclerosis Clinical Rheumatology, April 4, 2013

9 Can Serum Surfactant Protein D or CC-Chemokine Ligand 18 Predict Outcome of Interstitial Lung Disease in Patients with Early Systemic Sclerosis The Journal of Rheumatology, April 18, 2013

10 Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies Annals of Rheumatic Diseases, April 9, 2013

11 Relation of rheumatoid factor and anti-cyclic citrullinated peptide antibody with disease activity in rheumatoid arthritis: cross-sectional study Rheumatology International, April 26, 2013

12 Interleukin-6: a new therapeutic target in systemic sclerosis Clinical & Translational Immunology, April 19, 2013    Free full text    Review Article

13 Relationship between interleukin-6 and cardiac involvement in systemic sclerosis Rheumatology, April 1, 2013

14 Thrombosis in vasculitis Best Practice & Research Clinical Rheumatology, March 21, 2013    Review Article

15 ESSDAI and ESSPRI: EULAR indexes for a complete picture of primary Sjogrens syndrome patients Arthritis Care & Research , March 6, 2013    Review Article

16 Autoantibodies in Polymyositis and Dermatomyositis Current Rheumatology Reports, April 24, 2013    Review Article

17 Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile Annals of Rheumatic Diseases, April 15, 2013

18 Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases Arthritis Research & Therapy, April 5, 2013    Review Article

19 Anti-citrullinated protein antibodies (ACPA) in unaffected first degree relatives of rheumatoid arthritis patients Arthritis & Rheumatism, March 4, 2013

20 Update on Stem Cell Transplantation for Systemic Sclerosis: Recent Trial Results Current Rheumatology Reports, March 22, 2013    Review Article

Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatologymore

Other Topics in Rheumatology

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