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Rheumatology - Autoimmune/Heritable News & Articles
What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content
- Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
- MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Rheumatology
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Articles
Latest (2) Full Text Articles (22) Focus on Rheumatoid Arthritis981 Three cases of pneumatosis intestinalis presenting in autoimmune diseases Modern Rheumatology, November 18, 2011
982 Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population Disease Markers, November 18, 2011
983 Thyroid autoimmunity and recurrent miscarriage American Journal of Reproductive Immunology, November 17, 2011 Clinical Article
984 CD40 gene polymorphisms confer risk of Behcet's disease but not of Vogt–Koyanagi–Harada syndrome in a Han Chinese population Rheumatology, November 17, 2011
985 Analysis of Class II human leucocyte antigens in Italian and Spanish systemic sclerosis Rheumatology, November 17, 2011
986 Rapid infusion with rituximab: short term safety in systemic autoimmune diseases Rheumatology International, November 16, 2011
987 Increased finger skin vasoreactivity and stimulated vasomotion associated with simvastatin therapy in systemic sclerosis hypercholesterolemic patients Rheumatology International, November 11, 2011
988 The value of procalcitonin measurements in children with familial Mediterranean fever Rheumatology International, November 11, 2011
989 Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study Rheumatology, November 11, 2011
990 Evidence of a role for Th17 cells in breach of immune tolerance in arthritis Full Text Arthritis Research & Therapy, November 11, 2011
991 Initiation of tumor necrosis factor-{alpha} antagonists and the risk of hospitalization for infection in patients with autoimmune diseases Full Text JAMA, November 10, 2011 Clinical Article
992 Is there a real adrenal axis dysfunction in patients with amyloidosis associated with familial Mediterranean fever Rheumatology International, November 10, 2011
993 Coexistence of Autoimmune Polyglandular Syndrome Type 2 and Diabetes Insipidus in Pregnancy The American Journal of the Medical Sciences, November 10, 2011
994 Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population Diabetes/Metabolism Research and Reviews, November 10, 2011
995 Clinical research Genetic polymorphisms of CYP2D6 oxidation in patients with systemic lupus erythematosus Archives of Medical Science, November 10, 2011
996 Efficacy of etanercept in the tumor necrosis factor receptor-associated periodic syndrome (TRAPS) Arthritis & Rheumatism, November 9, 2011
997 Examining How Antiphospholipid Antibodies Activate Intracellular Signaling Pathways: A Systematic Review Seminars in Arthritis and Rheumatism, November 9, 2011 Evidence Based Medicine
998 Hypovitaminosis D and response to cholecalciferol supplementation in patients with autoimmune and non-autoimmune rheumatic diseases Rheumatology International, November 8, 2011
999 Application of Biomarkers to Clinical Trials in Systemic Sclerosis Current Rheumatology Reports, November 8, 2011
1000 Inhibition of Autoimmune Diabetes by TLR2 Tolerance Full Text The Journal of Immunology, November 8, 2011
Clinical Pearls in Rheumatology
- Independent predictors of disease activity in patients with systemic lupus include age, renal activity, immunosuppressant use and pre-existing organ damage
- When treating rheumatoid arthritis (RA), male sex, short duration of symptoms and less tender joints at baseline were found to be independent predictors of sustained remission with conventional DMARDs
- Higher baseline DAS28 scores and positive rheumatoid factor status are significantly associated with an improvement in response to rituximab treatment
Highlights in Rheumatology
ACPA correlate with disease progression in JIA
In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.
Read the article summaryPredicting cardiovascular mortality in SLE
In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.
Read the article summaryAnti-apoA-1 antibodies predict cardiovascular disease in RA patients
In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.
Read the article summaryMost Popular Rheumatology Articles
Last month's top read Top Articles of 20121 Targeted therapies for systemic sclerosis Nature Reviews Rheumatology , April 10, 2013
2 Current diagnostic tools for Sjogrens syndrome International Journal of Clinical Rheumatology, April 3, 2013
3 Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis Arthritis Research & Therapy, April 22, 2013
4 Antiphospholipid antibodies in children with systemic lupus erythematosus: a long-term clinical and laboratory follow-up status study from northwest India Rheumatology International, April 8, 2013
5 Skin and Mucosa Care in Systemic Sclerosis - Patients' and Family Caregivers' Experiences and Expectations of a Specific Education Programme: A Qualitative Study Musculoskeletal Care, March 28, 2013
6 The enhanced liver fibrosis test: a clinical grade, validated serum test, biomarker of overall fibrosis in systemic sclerosis Annals of Rheumatic Diseases, March 25, 2013
7 A meta-analysis of healing and prevention of digital ulcers (DU) in systemic sclerosis (SSc) Arthritis Care & Research , April 2, 2013 Evidence Based Medicine
8 Risk factors for body composition abnormalities in systemic sclerosis Clinical Rheumatology, April 4, 2013
9 Can Serum Surfactant Protein D or CC-Chemokine Ligand 18 Predict Outcome of Interstitial Lung Disease in Patients with Early Systemic Sclerosis The Journal of Rheumatology, April 18, 2013
10 Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies Annals of Rheumatic Diseases, April 9, 2013
11 Relation of rheumatoid factor and anti-cyclic citrullinated peptide antibody with disease activity in rheumatoid arthritis: cross-sectional study Rheumatology International, April 26, 2013
12 Interleukin-6: a new therapeutic target in systemic sclerosis Clinical & Translational Immunology, April 19, 2013 Free full text Review Article
13 Relationship between interleukin-6 and cardiac involvement in systemic sclerosis Rheumatology, April 1, 2013
14 Thrombosis in vasculitis Best Practice & Research Clinical Rheumatology, March 21, 2013 Review Article
15 ESSDAI and ESSPRI: EULAR indexes for a complete picture of primary Sjogrens syndrome patients Arthritis Care & Research , March 6, 2013 Review Article
16 Autoantibodies in Polymyositis and Dermatomyositis Current Rheumatology Reports, April 24, 2013 Review Article
17 Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile Annals of Rheumatic Diseases, April 15, 2013
18 Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases Arthritis Research & Therapy, April 5, 2013 Review Article
19 Anti-citrullinated protein antibodies (ACPA) in unaffected first degree relatives of rheumatoid arthritis patients Arthritis & Rheumatism, March 4, 2013
20 Update on Stem Cell Transplantation for Systemic Sclerosis: Recent Trial Results Current Rheumatology Reports, March 22, 2013 Review Article
Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatology more
Other Topics in Rheumatology
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