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Rheumatology - Autoimmune/Heritable News & Articles
What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content
- Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
- MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Rheumatology
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Articles
Latest (6) Full Text Articles (22) Focus on Osteoarthritis901 The innate immune response to enteroviruses and its possible role in regulating type 1 diabetes Clinical and Experimental Immunology, December 30, 2011
902 Typical Jaccouds arthropathy in a patient with sarcoidosis Rheumatology International, December 30, 2011
903 Successful pregnancies but a higher risk of preterm births in systemic sclerosis: An Italian multicentric study Arthritis & Rheumatism, December 30, 2011
904 Predictors of early mortality in systemic sclerosis: a case-control study comparing early versus late mortality in systemic sclerosis Rheumatology International, December 29, 2011
905 Risk factors for hepatocellular carcinoma in Japanese patients with autoimmune hepatitis type 1 Journal of Gastroenterology, December 29, 2011
906 Th17 cell cytokine secretion profile in host defense and autoimmunity Inflammation Research, December 28, 2011
907 Hepatitis C and autoimmunity: a therapeutic challenge Journal of Internal Medicine, December 28, 2011
908 Acquired haemophilia A in a woman with autoimmune hepatitis and systemic lupus erythematosus; review of literature Blood Coagulation & Fibrinolysis, December 28, 2011
909 Spectrum of autoimmune bullous diseases in Iran: a 10-year review International Journal of Dermatology, December 28, 2011
910 Mechanisms and Pathophysiology of Autoimmune Disease Clinical Reviews in Allergy and Immunology, December 27, 2011
911 Antibodies to Domain I of (beta)2Glycoprotein I are in close relation to patients risk categories in Antiphospholipid Syndrome (APS) Thrombosis Research, December 23, 2011
912 Evaluation of a new set of automated chemiluminescense assays for anticardiolipin and anti-beta2-glycoprotein I antibodies in the laboratory diagnosis of the antiphospholipid syndrome Thrombosis Research, December 23, 2011
913 White matter abnormalities in primary Sjogren syndrome QJM: An International Journal of Medicine, December 23, 2011
914 Airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity Arthritis & Rheumatism, December 22, 2011
915 Semiquantitative measurement of aquaporin-4 antibodies as a possible surrogate marker of neuromyelitis optica spectrum disorders with systemic autoimmune diseases Modern Rheumatology, December 22, 2011
916 Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails Annals of Rheumatic Diseases, December 22, 2011
917 The emerging relationship between neuromyelitis optica and systemic rheumatologic autoimmune disease Multiple Sclerosis Journal, December 22, 2011 Clinical Article
918 Measurement of autoantibodies in pediatric-onset systemic lupus erythematosus and their relationship with disease-associated manifestations Seminars in Arthritis and Rheumatism, December 21, 2011
919 Pulmonary arterial hypertension therapy may be safe and effective in patients with systemic sclerosis and borderline pulmonary pressures Arthritis & Rheumatism, December 21, 2011
920 Antiphospholipid Antibodies in Malignancy: Are These Pathogenic or Epiphenomena JCR: Journal of Clinical Rheumatology, December 21, 2011
Clinical Pearls in Rheumatology
- Independent predictors of disease activity in patients with systemic lupus include age, renal activity, immunosuppressant use and pre-existing organ damage
- When treating rheumatoid arthritis (RA), male sex, short duration of symptoms and less tender joints at baseline were found to be independent predictors of sustained remission with conventional DMARDs
- Higher baseline DAS28 scores and positive rheumatoid factor status are significantly associated with an improvement in response to rituximab treatment
Highlights in Rheumatology
ACPA correlate with disease progression in JIA
In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.
Read the article summaryPredicting cardiovascular mortality in SLE
In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.
Read the article summaryAnti-apoA-1 antibodies predict cardiovascular disease in RA patients
In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.
Read the article summaryMost Popular Rheumatology Articles
Last month's top read Top Articles of 20121 Targeted therapies for systemic sclerosis Nature Reviews Rheumatology , April 10, 2013
2 Current diagnostic tools for Sjogrens syndrome International Journal of Clinical Rheumatology, April 3, 2013
3 Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis Arthritis Research & Therapy, April 22, 2013
4 Antiphospholipid antibodies in children with systemic lupus erythematosus: a long-term clinical and laboratory follow-up status study from northwest India Rheumatology International, April 8, 2013
5 Skin and Mucosa Care in Systemic Sclerosis - Patients' and Family Caregivers' Experiences and Expectations of a Specific Education Programme: A Qualitative Study Musculoskeletal Care, March 28, 2013
6 The enhanced liver fibrosis test: a clinical grade, validated serum test, biomarker of overall fibrosis in systemic sclerosis Annals of Rheumatic Diseases, March 25, 2013
7 A meta-analysis of healing and prevention of digital ulcers (DU) in systemic sclerosis (SSc) Arthritis Care & Research , April 2, 2013 Evidence Based Medicine
8 Risk factors for body composition abnormalities in systemic sclerosis Clinical Rheumatology, April 4, 2013
9 Can Serum Surfactant Protein D or CC-Chemokine Ligand 18 Predict Outcome of Interstitial Lung Disease in Patients with Early Systemic Sclerosis The Journal of Rheumatology, April 18, 2013
10 Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies Annals of Rheumatic Diseases, April 9, 2013
11 Relation of rheumatoid factor and anti-cyclic citrullinated peptide antibody with disease activity in rheumatoid arthritis: cross-sectional study Rheumatology International, April 26, 2013
12 Interleukin-6: a new therapeutic target in systemic sclerosis Clinical & Translational Immunology, April 19, 2013 Free full text Review Article
13 Relationship between interleukin-6 and cardiac involvement in systemic sclerosis Rheumatology, April 1, 2013
14 Thrombosis in vasculitis Best Practice & Research Clinical Rheumatology, March 21, 2013 Review Article
15 ESSDAI and ESSPRI: EULAR indexes for a complete picture of primary Sjogrens syndrome patients Arthritis Care & Research , March 6, 2013 Review Article
16 Autoantibodies in Polymyositis and Dermatomyositis Current Rheumatology Reports, April 24, 2013 Review Article
17 Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile Annals of Rheumatic Diseases, April 15, 2013
18 Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases Arthritis Research & Therapy, April 5, 2013 Review Article
19 Anti-citrullinated protein antibodies (ACPA) in unaffected first degree relatives of rheumatoid arthritis patients Arthritis & Rheumatism, March 4, 2013
20 Update on Stem Cell Transplantation for Systemic Sclerosis: Recent Trial Results Current Rheumatology Reports, March 22, 2013 Review Article
Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatology more
Other Topics in Rheumatology
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