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Rheumatology - Autoimmune/Heritable News & Articles
What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content
- Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
- MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
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Articles
Latest (2) Full Text Articles (22) Focus on Fibromyalgia361 Bone mass and vitamin D in patients with systemic sclerosis from two Spanish regions Clinical and Experimental Rheumatology Online, January 4, 2013 Clinical Guideline
362 Long-term clinical outcomes and risk factors for the occurrence of post-operative complications after cardiovascular surgery in patients with Behcet`s disease Clinical and Experimental Rheumatology Online, January 4, 2013 Clinical Guideline
363 Aortic pulse wave velocity measurement in systemic sclerosis patients Full Text Rheumatismo, January 3, 2013
364 Insights into Behcet’s disease Advances in Dermatology and Allergology, January 3, 2013 Review Article
365 Clinical significance of peripheral blood lymphocyte subsets in patients with polymyositis and dermatomyositis Clinical Rheumatology, January 3, 2013 Clinical Guideline
366 Clinical and serological features of systemic sclerosis in a Chinese cohort Clinical Rheumatology, January 3, 2013 Clinical Guideline
367
Borderline mean pulmonary artery pressure in systemic sclerosis patients: Trans-pulmonary gradient predicts risk of developing pulmonary hypertension
Arthritis & Rheumatism, January 2, 2013
Clinical Guideline
Clinical Article
Exclusive Author Commentary
368 Differential role of lipocalin-2 during immune-complex mediated acute and chronic inflammation Arthritis & Rheumatism, January 2, 2013 Review Article
369 Treatment of refractory obstetric antiphospholipid syndrome: the state of the art and new trends in the therapeutic management Lupus, December 31, 2012
370 Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation Annals of Rheumatic Diseases, December 31, 2012
371 KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor Full Text Arthritis Research & Therapy, December 28, 2012
372 Prognosis of scleroderma renal crisis: a long-term observational study Nephrology Dialysis Transplantation, December 27, 2012
373 Initiation of Tumor Necrosis Factor Alpha (TNFα) antagonists and risk of fractures in patients with selected rheumatic and autoimmune diseases Arthritis Care & Research , December 26, 2012
374 Determining the prevalence of antineutrophil cytoplasmic antibody and the cut-offs of anti-PR3 and anti-MPO antibody in general population Indian Journal of Rheumatology , December 21, 2012
375 Circulating γ/δ T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts Journal of Dermatological Science, December 20, 2012
376 Extent of disease on high-resolution computed tomography lung is a predictor of decline and mortality in systemic sclerosis-related interstitial lung disease Rheumatology, December 20, 2012
377 Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients Full Text Rheumatismo, December 20, 2012
378 Diagnostic value of biopsies in identifying cytoplasmic antineutrophil cytoplasmic antibody-negative localized Wegeners granulomatosis presenting primarily with sinonasal disease The American Journal of Rhinology & Allergy, December 20, 2012
379
Serum B-cell activating factor assessment in a population of Egyptian patients with systemic sclerosis
International Journal of Rheumatic Diseases, December 19, 2012
Exclusive Author Commentary
380 Increased Serum Immunoglobulin A Antiphospholipid Antibody Levels in Childhood Henoch-Schonlein Purpura Turkish Journal of Rheumatology, December 19, 2012
Clinical Pearls in Rheumatology
- Independent predictors of disease activity in patients with systemic lupus include age, renal activity, immunosuppressant use and pre-existing organ damage
- When treating rheumatoid arthritis (RA), male sex, short duration of symptoms and less tender joints at baseline were found to be independent predictors of sustained remission with conventional DMARDs
- Higher baseline DAS28 scores and positive rheumatoid factor status are significantly associated with an improvement in response to rituximab treatment
Highlights in Rheumatology
ACPA correlate with disease progression in JIA
In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.
Read the article summaryPredicting cardiovascular mortality in SLE
In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.
Read the article summaryAnti-apoA-1 antibodies predict cardiovascular disease in RA patients
In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.
Read the article summaryMost Popular Rheumatology Articles
Last month's top read Top Articles of 20121 Targeted therapies for systemic sclerosis Nature Reviews Rheumatology , April 10, 2013
2 Current diagnostic tools for Sjogrens syndrome International Journal of Clinical Rheumatology, April 3, 2013
3 Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis Arthritis Research & Therapy, April 22, 2013
4 Antiphospholipid antibodies in children with systemic lupus erythematosus: a long-term clinical and laboratory follow-up status study from northwest India Rheumatology International, April 8, 2013
5 Skin and Mucosa Care in Systemic Sclerosis - Patients' and Family Caregivers' Experiences and Expectations of a Specific Education Programme: A Qualitative Study Musculoskeletal Care, March 28, 2013
6 The enhanced liver fibrosis test: a clinical grade, validated serum test, biomarker of overall fibrosis in systemic sclerosis Annals of Rheumatic Diseases, March 25, 2013
7 A meta-analysis of healing and prevention of digital ulcers (DU) in systemic sclerosis (SSc) Arthritis Care & Research , April 2, 2013 Evidence Based Medicine
8 Risk factors for body composition abnormalities in systemic sclerosis Clinical Rheumatology, April 4, 2013
9 Can Serum Surfactant Protein D or CC-Chemokine Ligand 18 Predict Outcome of Interstitial Lung Disease in Patients with Early Systemic Sclerosis The Journal of Rheumatology, April 18, 2013
10 Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies Annals of Rheumatic Diseases, April 9, 2013
11 Relation of rheumatoid factor and anti-cyclic citrullinated peptide antibody with disease activity in rheumatoid arthritis: cross-sectional study Rheumatology International, April 26, 2013
12 Interleukin-6: a new therapeutic target in systemic sclerosis Clinical & Translational Immunology, April 19, 2013 Free full text Review Article
13 Relationship between interleukin-6 and cardiac involvement in systemic sclerosis Rheumatology, April 1, 2013
14 Thrombosis in vasculitis Best Practice & Research Clinical Rheumatology, March 21, 2013 Review Article
15 ESSDAI and ESSPRI: EULAR indexes for a complete picture of primary Sjogrens syndrome patients Arthritis Care & Research , March 6, 2013 Review Article
16 Autoantibodies in Polymyositis and Dermatomyositis Current Rheumatology Reports, April 24, 2013 Review Article
17 Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile Annals of Rheumatic Diseases, April 15, 2013
18 Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases Arthritis Research & Therapy, April 5, 2013 Review Article
19 Anti-citrullinated protein antibodies (ACPA) in unaffected first degree relatives of rheumatoid arthritis patients Arthritis & Rheumatism, March 4, 2013
20 Update on Stem Cell Transplantation for Systemic Sclerosis: Recent Trial Results Current Rheumatology Reports, March 22, 2013 Review Article
Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatology more
Other Topics in Rheumatology
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