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Rheumatology - Connective Tissue Dz News & Articles
What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content
- Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
- MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Rheumatology
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Articles
Latest Full Text Articles (5) Focus on Rheumatoid Arthritis421 The effect of flashlamp pulsed dye laser on the expression of connective tissue growth factor in keloids Lasers in Surgery and Medicine, May 8, 2012
422 Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis Full Text Arthritis Research & Therapy, May 8, 2012
423 The six-minute walk test using forehead oximetry is reliable in the assessment of scleroderma lung disease Respirology, May 7, 2012
424 The expression of APRIL in Sjogren’s syndrome: aberrant expression of APRIL in the salivary gland Rheumatology, May 7, 2012
425 Nervous system involvement of connective tissue disease: mechanisms and diagnostic approach Current Opinion in Neurology, May 7, 2012
426 Validation of the scleroderma health assessment questionnaire and quality of life in English and Chinese-speaking patients with systemic sclerosis International Journal of Rheumatic Diseases, May 4, 2012
427 Critical limb ischemia in systemic sclerosis Zeitschrift für Rheumatologie, May 2, 2012
428 Candidate gene study in systemic sclerosis identifies a rare and functional variant of TNFAIP3 locus as a risk factor for individual polyautoimmunity Arthritis & Rheumatism, May 2, 2012
429 Clinical analysis of 50 children with juvenile dermatomyositis Modern Rheumatology, May 1, 2012 Clinical Article
430 Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: What we still have to learn? Rheumatology International, May 1, 2012
431 Articular involvement in systemic sclerosis Rheumatology, April 30, 2012
432 Prevalence of systemic sclerosis in south-east Norway Rheumatology, April 27, 2012
433 Incidence and prevalence of idiopathic inflammatory myopathies in South Australia: a 30-year epidemiologic study of histology-proven cases International Journal of Rheumatic Diseases, April 27, 2012
434 Autoantibodies to transcription intermediary factor (TIF)1beta associated with dermatomyositis Full Text Arthritis Research & Therapy, April 26, 2012
435 A multicentre study confirms CD226 gene association with Systemic Sclerosis-related pulmonary fibrosis Full Text Arthritis Research & Therapy, April 25, 2012
436 Maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis Rheumatology, April 24, 2012
437 Calcinosis Cutis Occurring in Association With Autoimmune Connective Tissue Disease JAMA Dermatology, April 23, 2012
438 Exercise training in juvenile dermatomyositis Arthritis Care & Research , April 19, 2012
439 The Association of Illness Perceptions with Physical and Mental Health in Systemic Sclerosis Patients: An Exploratory Study Musculoskeletal Care, April 19, 2012
440 Accumulation of mature B cells in the inflamed muscle tissue of a patient with anti-155/140 antibody-positive juvenile dermatomyositis Modern Rheumatology, April 19, 2012
Clinical Pearls in Rheumatology
- Independent predictors of disease activity in patients with systemic lupus include age, renal activity, immunosuppressant use and pre-existing organ damage
- When treating rheumatoid arthritis (RA), male sex, short duration of symptoms and less tender joints at baseline were found to be independent predictors of sustained remission with conventional DMARDs
- Higher baseline DAS28 scores and positive rheumatoid factor status are significantly associated with an improvement in response to rituximab treatment
Highlights in Rheumatology
ACPA correlate with disease progression in JIA
In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.
Read the article summaryPredicting cardiovascular mortality in SLE
In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.
Read the article summaryAnti-apoA-1 antibodies predict cardiovascular disease in RA patients
In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.
Read the article summaryMost Popular Rheumatology Articles
Last month's top read Top Articles of 20121 Current diagnostic tools for Sjogrens syndrome International Journal of Clinical Rheumatology, April 3, 2013
2 Cancer incidence in systemic sclerosis: Meta-analysis of population-based cohort studies Arthritis & Rheumatism, April 11, 2013 Evidence Based Medicine
3 Sarcoidosis and Sjogrens syndrome: clinical and salivary evaluation Journal of Oral Pathology & Medicine, March 27, 2013 Review Article
4 A meta-analysis of healing and prevention of digital ulcers (DU) in systemic sclerosis (SSc) Arthritis Care & Research , April 2, 2013 Evidence Based Medicine
5 Novel aspects of Sjogren's syndrome in 2012 BMC Medicine, April 16, 2013 Free full text
6 Risk factors for body composition abnormalities in systemic sclerosis Clinical Rheumatology, April 4, 2013
7 Skin and Mucosa Care in Systemic Sclerosis - Patients' and Family Caregivers' Experiences and Expectations of a Specific Education Programme: A Qualitative Study Musculoskeletal Care, March 28, 2013
8 Targeted therapies for systemic sclerosis Nature Reviews Rheumatology , April 10, 2013
9 Anti B-cell therapy against refractory thrombocytopenia in SLE and MCTD patients: long-term follow-up and review of the literature Lupus, April 25, 2013
10 Mycophenolate Mofetil Improves Lung Function in Connective Tissue Disease-associated Interstitial Lung Disease The Journal of Rheumatology, March 6, 2013
11 Relationship between interleukin-6 and cardiac involvement in systemic sclerosis Rheumatology, April 1, 2013
12 Cryofibrinogenemia JCR: Journal of Clinical Rheumatology, March 29, 2013 Review Article
13 No association of primary Sjögren’s syndrome with Fcγ receptor gene variants Genes and Immunity, April 12, 2013 Review Article
14 Undifferentiated connective tissue disease in a rheumatology center in Cali, Colombia: clinical features of 94 patients followed for a year Rheumatology International, April 8, 2013
15 Rationale for treating primary Sjogrens syndrome patients with an anti-CD6 monoclonal antibody (Itolizumab) Immunologic Research, April 26, 2013 Review Article
16 Rheumatic manifestations in primary hypothyroidism Indian Journal of Rheumatology , March 28, 2013
17 Update on Stem Cell Transplantation for Systemic Sclerosis: Recent Trial Results Current Rheumatology Reports, March 22, 2013 Review Article
18 Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara Arthritis Research & Therapy, April 5, 2013
19 Assessment of left ventricular functions in patients with Sjogrens syndrome using tissue doppler echocardiography International Journal of Rheumatic Diseases, April 11, 2013
20 Functional articular cartilage repair: here, near, or is the best approach not yet clear Nature Reviews Rheumatology , March 20, 2013 Review Article
Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatology more
Other Topics in Rheumatology
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