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Rheumatology - Basic Science/Genetics News & Articles

What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content

  • Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
  • MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

Your Unread Messages in Rheumatology

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Articles

Latest (4) Full Text Articles (33) Focus on Osteoarthritis
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

1 MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes Annals of Rheumatic Diseases, May 22, 2013    Review Article

2 Microarray-based gene expression profiling in patients with cryopyrin-associated periodic syndromes defines a disease-related signature and IL-1-responsive transcripts Annals of Rheumatic Diseases, May 22, 2013    Review Article

3 Insights in the relationship of joint space narrowing versus erosive joint damage and physical functioning of patients with RA Annals of Rheumatic Diseases, May 22, 2013    Review Article

4 Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2 Annals of Rheumatic Diseases, May 22, 2013    Review Article

Prior Articles

5 Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data Annals of Rheumatic Diseases, May 21, 2013    Review Article

6 The concentration of anticitrullinated protein antibodies in serum and synovial fluid in relation to total immunoglobulin concentrations Annals of Rheumatic Diseases, May 21, 2013    Review Article

7 Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS) Annals of Rheumatic Diseases, May 21, 2013    Review Article

8 The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis Annals of Rheumatic Diseases, May 21, 2013    Review Article

9 Muscle cell-derived factors inhibit inflammatory stimuli-induced damage in hMSC-derived chondrocytes Osteoarthritis and Cartilage , May 21, 2013    Review Article

10 Premature cell senescence and T cell receptor-independent activation of CD8T cells in Juvenile Idiopathic Arthritis Arthritis & Rheumatism, May 20, 2013    Review Article

11 Introduction to statistical modelling 2: categorical variables and interactions in linear regression Rheumatology, May 20, 2013    Review Article

12 Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation Arthritis & Rheumatism, May 20, 2013    Review Article

13 C/EBPα regulates osteoclast lineage commitment Proceedings of the National Academy of Sciences of the United States of America, May 20, 2013    Review Article

14 MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic effects in human articular chondrocytes Osteoarthritis and Cartilage , May 16, 2013    Review Article

15 WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta New England Journal of Medicine, May 15, 2013    Review Article

16 Histopathological changes in tendinopathy--potential roles of BMPs Rheumatology, May 15, 2013    Review Article

17 Dnase1l3 mutations in hypocomplementemic urticarial vasculitis syndrome Arthritis & Rheumatism, May 14, 2013    Review Article

18 Layilin, a talin-binding hyaluronan receptor, is expressed in human articular chondrocytes and synoviocytes and is down-regulated by interleukin-1β Modern Rheumatology, May 14, 2013    Review Article

19 Location of CD4+ T Cell Priming Regulates the Differentiation of Th1 and Th17 Cells and Their Contribution to Arthritis The Journal of Immunology, May 13, 2013    Review Article

20 Osteoprotegerin causes apoptosis of endothelial progenitor cells by induction of oxidative stress Arthritis & Rheumatism, May 13, 2013    Review Article

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Clinical Pearls in Rheumatology

Highlights in Rheumatology

ACPA correlate with disease progression in JIA

In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.

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Predicting cardiovascular mortality in SLE

In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.

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Anti-apoA-1 antibodies predict cardiovascular disease in RA patients

In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.

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Most Popular Rheumatology Articles

Last month's top read Top Articles of 2012

1 Medical students attitude towards rheumatology training at foundation years level in the UK and rationale behind the students choice: results from a national survey Rheumatology International, April 11, 2013

2 Therapeutics for the treatment of spondyloarthritis: what, when and whom International Journal of Clinical Rheumatology, March 25, 2013

3 Using cyclophosphamide in inflammatory rheumatic diseases European Journal of Internal Medicine , March 29, 2013    Review Article

4 The Genetics of Psoriasis and Psoriatic Arthritis Clinical Reviews in Allergy and Immunology, March 18, 2013    Review Article

5 The phenotypic and genetic signatures of common musculoskeletal pain conditions Nature Reviews Rheumatology , April 4, 2013    Review Article

6 Gene Expression of Catalytic Proteasome Subunits and Resistance Toward Proteasome Inhibition of B Lymphocytes from Patients with Primary Sjogren Syndrome The Journal of Rheumatology, March 19, 2013    Review Article

7 Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases Arthritis Research & Therapy, April 5, 2013    Review Article

8 Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions Current Opinion in Rheumatology, April 2, 2013    Review Article

9 The ascent of acetylation in the epigenetics of rheumatoid arthritis Nature Reviews Rheumatology , March 4, 2013    Review Article

10 Reaching the Threshold: A Multilayer Pathogenesis of Macrophage Activation Syndrome The Journal of Rheumatology, April 17, 2013    Review Article

11 Cortical remodeling during menopause, rheumatoid arthritis, glucocorticoid and bisphosphonate therapy Arthritis Research & Therapy, March 25, 2013    Review Article

12 Salubrinal reduces expression and activity of MMP13 in chondrocytes Osteoarthritis and Cartilage , April 1, 2013    Review Article

13 Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile Annals of Rheumatic Diseases, April 15, 2013

14 MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc Arthritis Research & Therapy, April 29, 2013    Review Article

15 Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer Osteoarthritis and Cartilage , April 24, 2013    Review Article

16 The TNF-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-kB signaling Arthritis & Rheumatism, January 18, 2013

17 Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis Annals of Rheumatic Diseases, April 10, 2013    Review Article

18 TNF inhibitors induce discoid fibrosis in the sublining layers of the synovium with degeneration of synoviocytes in rheumatoid arthritis Rheumatology International, April 17, 2013    Review Article

19 Update on polymyalgia rheumatica European Journal of Internal Medicine , April 12, 2013

20 Opportunistic Screening for Osteoporosis Using Abdominal Computed Tomography Scans Obtained for Other Indications Annals of Internal Medicine, April 17, 2013

Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatologymore

Other Topics in Rheumatology

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