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Rheumatology - Basic Science/Genetics News & Articles

What you'll find here at MDLinx Rheumatology: The top rheumatology clinical articles of the day, plus MDLinx exclusive content

  • Our medical editors bring you the best key learnings published in the top peer-reviewed rheumatology medical journals. You'll find overviews here ranked and organized by topic on rheumatoid arthritis, joint and back pain, osteoarthritis, lupus and autoimmune diseases, osteoporosis and bone fractures. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
  • MDLinx exclusive content includes monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, as well as clinical pearls from The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

Your Unread Messages in Rheumatology

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Articles

Latest (4) Full Text Articles (33) Focus on Gout
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

61 Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay Arthritis Research & Therapy, April 16, 2013    Review Article

62 Replication of Caucasian loci associated with bone mineral density in Koreans Osteoporosis International, April 16, 2013    Review Article

63 The presenting manifestations of subcutaneous panniculitis-like T-cell lymphoma and T-cell lymphoma and cutaneous γδ T-cell lymphoma may mimic those of rheumatic diseases: a report of 11 cases Clinical Rheumatology, April 16, 2013    Review Article

64 tPA Alu (I/D) polymorphism associates with bacterial osteomyelitis The Journal of Infectious Diseases, April 16, 2013    Review Article

65 Effect of hypoxia/reoxygenation on the cytokine-induced production of nitric oxide and superoxide anion in cultured osteoarthritic synoviocytes Osteoarthritis and Cartilage , April 16, 2013    Review Article

66 Brain amyloid-β oligomers in ageing and Alzheimers disease Brain, April 16, 2013    Review Article

67 Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile Annals of Rheumatic Diseases, April 15, 2013    Clinical Article

68 Prevalence of interferon type I signature in CD14 monocytes of patients with Sjogrens syndrome and association with disease activity and BAFF gene expression Annals of Rheumatic Diseases, April 15, 2013    Review Article

69 C-reactive protein inhibits plasmacytoid dendritic cell interferon responses to autoantibody immune complexes Arthritis & Rheumatism, April 15, 2013    Clinical Article

70 The FCRL3 -169T>C polymorphism might be associated with some autoantibody presence in patients with SLE in a Polish population Modern Rheumatology, April 15, 2013    Review Article

71 Glucocorticoids suppress T cell function by upregulating microRNA 98 Arthritis & Rheumatism, April 15, 2013    Review Article
Exclusive Author Commentary

72 Update on polymyalgia rheumatica European Journal of Internal Medicine , April 12, 2013    Clinical Article

73 Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis Cytokine, April 12, 2013    Review Article

74 No association of primary Sjögren’s syndrome with Fcγ receptor gene variants Genes and Immunity, April 12, 2013    Review Article

75 Mesenchymal Stem Cells (MSCs) from Scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular based therapy Clinical and Experimental Immunology, April 12, 2013    Review Article

76 Medical students attitude towards rheumatology training at foundation years level in the UK and rationale behind the students choice: results from a national survey Rheumatology International, April 11, 2013    Clinical Article

77 Independent and conjoint associations of gout and hyperuricaemia with total and cardiovascular mortality QJM: An International Journal of Medicine, April 11, 2013    Clinical Article

78 Class I HDAC inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation Arthritis & Rheumatism, April 11, 2013    Review Article

79 Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis Annals of Rheumatic Diseases, April 10, 2013    Review Article

80 Coexistence of two rare genetic disorders: Kartagener syndrome and familial Mediterranean fever Modern Rheumatology, April 10, 2013    Review Article

50 available pages First Previous 4 5 6 7 8 9 10 11 12 13 Next Last

Clinical Pearls in Rheumatology

Highlights in Rheumatology

ACPA correlate with disease progression in JIA

In a study involving 74 patients with juvenile idiopathic arthritis (JIA), 26 patients had detectable anti-citrullinated protein antibodies (ACPA). The ACPA titers correlated with disease progression at baseline and after a median follow-up of 11.5 months. In addition to predicting disease severity and progression, the authors concluded that ACPA were superior to IgM-RF in diagnosing JIA.

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Predicting cardiovascular mortality in SLE

In a study involving 208 patients with SLE followed for 12 years, 42 deaths occurred, 48% of which were considered to be cardiovascular mortalities. Age, increased cystatin C levels, and arterial disease were predictive of all-cause mortality. Cigarette smoking and increased sVCAM-1, hsCRP, abeta2GP1, and aPL antibody levels were predictive of cardiovascular mortality.

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Anti-apoA-1 antibodies predict cardiovascular disease in RA patients

In a study conducted at the University of Geneva involving 118 patients with rheumatoid arthritis, but without cardiovascular disease at baseline, the 10-year Framingham cardiovascular risk score (FRS) was improved with the inclusion of the anti-apoA-1 antibody titer. The median follow-up was 9 years and the incidence of cardiovascular disease was 16%. Other biomarkers, including the NT-proBNP, oxLDL, CRP, and RF levels and the anti-citrullinated peptide antibody titer, did not improve the FRS.

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Most Popular Rheumatology Articles

Last month's top read Top Articles of 2012

1 Medical students attitude towards rheumatology training at foundation years level in the UK and rationale behind the students choice: results from a national survey Rheumatology International, April 11, 2013

2 Therapeutics for the treatment of spondyloarthritis: what, when and whom International Journal of Clinical Rheumatology, March 25, 2013

3 Using cyclophosphamide in inflammatory rheumatic diseases European Journal of Internal Medicine , March 29, 2013    Review Article

4 The Genetics of Psoriasis and Psoriatic Arthritis Clinical Reviews in Allergy and Immunology, March 18, 2013    Review Article

5 The phenotypic and genetic signatures of common musculoskeletal pain conditions Nature Reviews Rheumatology , April 4, 2013    Review Article

6 Gene Expression of Catalytic Proteasome Subunits and Resistance Toward Proteasome Inhibition of B Lymphocytes from Patients with Primary Sjogren Syndrome The Journal of Rheumatology, March 19, 2013    Review Article

7 Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases Arthritis Research & Therapy, April 5, 2013    Review Article

8 Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions Current Opinion in Rheumatology, April 2, 2013    Review Article

9 The ascent of acetylation in the epigenetics of rheumatoid arthritis Nature Reviews Rheumatology , March 4, 2013    Review Article

10 Reaching the Threshold: A Multilayer Pathogenesis of Macrophage Activation Syndrome The Journal of Rheumatology, April 17, 2013    Review Article

11 Cortical remodeling during menopause, rheumatoid arthritis, glucocorticoid and bisphosphonate therapy Arthritis Research & Therapy, March 25, 2013    Review Article

12 Salubrinal reduces expression and activity of MMP13 in chondrocytes Osteoarthritis and Cartilage , April 1, 2013    Review Article

13 Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile Annals of Rheumatic Diseases, April 15, 2013

14 MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc Arthritis Research & Therapy, April 29, 2013    Review Article

15 Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer Osteoarthritis and Cartilage , April 24, 2013    Review Article

16 The TNF-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-kB signaling Arthritis & Rheumatism, January 18, 2013

17 Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis Annals of Rheumatic Diseases, April 10, 2013    Review Article

18 TNF inhibitors induce discoid fibrosis in the sublining layers of the synovium with degeneration of synoviocytes in rheumatoid arthritis Rheumatology International, April 17, 2013    Review Article

19 Update on polymyalgia rheumatica European Journal of Internal Medicine , April 12, 2013

20 Opportunistic Screening for Osteoporosis Using Abdominal Computed Tomography Scans Obtained for Other Indications Annals of Internal Medicine, April 17, 2013

Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatologymore

Other Topics in Rheumatology

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