Mortality increased in juvenile-onset SLE
As reported in Rheumatology, juvenile-onset SLE is associated with increased lupus nephritis, hemolytic anemia, and mortality compared to adult-onset SLE.
Fluvastatin improves pro-inflammatory and pro-thrombotic markers in aPL-positive patients
As reported in the Annals of Rheumatic Diseases, treatment of persistent aPL-positive patients with fluvastatin (40 mg qd x 3 months) improved pro-inflammatory and pro-thrombotic markers (IL1-β, VEGF, TNF-α, IP10, sCD40L, and sTF).
FCGR3B loss increases susceptibility to SLE and LN
As reported in the International Journal of Rheumatic Diseases, a meta-analysis of 6 studies has shown that a loss of FCGR3B copy number is associated with increased susceptibility to SLE (OR=1.77) and lupus nephritis (OR=2.02).