The Latest Clinical Articles in Rheumatology

1Vitamin D status and its association with quality of life, physical activity, and disease activity in rheumatoid arthritis patientsJCR: Journal of Clinical Rheumatology, March 31, 2015  Clinical Article
2New insights into the measurement of disease activity in rheumatoid arthritisCurrent Opinion in Rheumatology, March 31, 2015  Review Article
3Socio-economic status and the risk of developing hand, hip or knee osteoarthritis: A region-wide ecological studyOsteoarthritis and Cartilage , March 31, 2015  Clinical Article
4Glucocorticoid with or without additional immunosuppressant therapy for patients with lupus podocytopathy: A retrospective single-center studyLupus, March 31, 2015  Clinical Article
5Assessing the prevalence of compromised bone health among overweight and obese African-American breast cancer survivors: a case–control studyJournal of Cancer Survivorship, March 31, 2015  Clinical Article
6Primary prophylaxis to prevent obstetric complications in asymptomatic women with antiphospholipid antibodies: A systematic reviewLupus, March 31, 2015  Review Article
7An examination of the mechanisms involved in secondary clinical failure to adalimumab or etanercept in inflammatory arthropathiesJCR: Journal of Clinical Rheumatology, March 31, 2015  Clinical Article
8DNA methylome signature in early rheumatoid arthritis synoviocytes compared with longstanding rheumatoid arthritis synoviocytesArthritis & Rheumatism, March 31, 2015  Clinical Article
9Genetic contribution to osteoarthritis development: Current state of evidenceCurrent Opinion in Rheumatology, March 31, 2015  Review Article
10Young peoples decisions about biologic therapies: Who influences them and how?Rheumatology, March 31, 2015  Clinical Article
1Corticosteroid injections linked to joint deteriorationClinical Orthopedics and Related Research, March 30, 2015
2American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
3Combating osteoporosis before a hip breaksLinköping University News, March 18, 2015

Show Me:

Fluvastatin improves pro-inflammatory and pro-thrombotic markers in aPL-positive patients

As reported in the Annals of Rheumatic Diseases, treatment of persistent aPL-positive patients with fluvastatin (40 mg qd x 3 months) improved pro-inflammatory and pro-thrombotic markers (IL1-β, VEGF, TNF-α, IP10, sCD40L, and sTF).

Metacarpal DXR-BMD predicts 1-y RA progression

As reported in the Annals of Rheumatic Diseases, a metacarpal BMD determination after 4 months of anti-RA treatment is an independent predictor of 1-y progression in patients without baseline bone erosions (OR=2.0). For patients with baseline erosions, early metacarpal BMD loss is predictive of 1-y progression (OR=1.5).

Low vitamin D associated with statin-induced myalgia

As reported in Clinical Therapeutics, of 450 patients prescribed high-dose simvastatin (80 mg qd) for dyslipidemia, 11.1% complained of myalgias. The vitamin D level was lower in patients with myalgias than patients without myalgias (26.2 vs. 36.3 ng/mL).

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Clinical Pearls

Clinical Pearl from Smartest DocLupus erythematosus can be induced through known pharmacologic interactions.

Clinical Pearl from Smartest DocAccording to American College of Rheumatology classification, a patient is said to have Churg-Strauss syndrome if at least 4 of 6 criteria are present.

Clinical Pearl from Smartest DocEULAR defines “erosive disease” in light of 2010 ACR/EUR RA classification criteria

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