Leptin promotes lupus T-cell autoimmunity

Clinical Immunology, 09/27/2013

In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here the authors show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T–cells in mice with an autoreactive T–cell repertoire, including (NZB x NZW)F1 lupus–prone model. This ability of leptin to promote lupus T–cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE.

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