Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation
Journal of Bone and Mineral Research,  Review Article

Oppenheimer H et al. – Type II collagen is a key cartilaginous extracellular protein required for normal endorchondral development and cartilage homeostasis. COL2A1 gene expression is positively regulated by the NAD–dependent protein deacetylase SirT1, through its ability to bind chromatin regions of the COL2A1 promoter and enhancer. The study indicates that Set7/9 prevents the histone deacetylase activity of SirT1, potentiating euchromatin formation on the promoter site of COL2A1 and resulting in morphology–dependent COL2A1 gene transactivation.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Rheumatology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Rheumatology Articles

Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatologymore