3D assessment of cortical bone porosity and tissue mineral density using high-resolution micro-CT: Effects of resolution and threshold method

Journal of Bone and Mineral Research, 06/17/2013

Current micro–CT systems allow scanning bone at resolutions capable of three–dimensional characterization of intracortical vascular porosity and osteocyte lacunae. However, the scanning and reconstruction parameters along with the image segmentation method affect the accuracy of the measurements. If measuring cortical vascular microarchitecture, especially in small animals, a micro–CT resolution of 1 – 2 µm is appropriate, while a resolution of at least 1 µm is necessary when assessing osteocyte lacunar porosity.

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