Limitations of global morphometry in predicting trabecular bone failure

Journal of Bone and Mineral Research, 06/13/2013

Efforts in finding independent measures for accurate and reliable prediction of trabecular bone failure have led to the development of a number of morphometric indices characterizing trabecular bone microstructure. Investigating three–dimensional animations of structural bone failure, the authors could demonstrate that two main failure mechanisms determine the competence of trabecular bone samples; in homogeneous, isotropic trabecular bone samples, competence is determined by a whole set of trabecular elements, whereas in inhomogeneous, anisotropic bone samples a single or a missing trabeculae may induce catastrophic failure. The later failure mechanism cannot be described by conventional morphometry indicating the need for novel morphometric indices also applicable to the prediction of failure in inhomogeneous bone samples.

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