Bone and skeletal muscle: neighbors with close ties

Journal of Bone and Mineral Research, 05/09/2013

The musculoskeletal system evolved in mammals to perform diverse functions that include locomotion, facilitating breathing, protecting internal organs, and coordinating global energy expenditure. Age–associated sarcopenia results in reduced endurance, poor balance and reduced mobility that predispose elderly individuals to falls, which more frequently result in fracture because of concomitant osteoporosis. Thus, a better understanding of the mechanisms underlying the parallel development and involution of these tissues is critical to developing new and more effective means to combat osteoporosis and sarcopenia in the increasingly aged population.

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