Chd4 and associated proteins function as corepressors of Sox9 expression during BMP-2-induced chondrogenesis

Journal of Bone and Mineral Research, 03/26/2013

The authors took advantage of quantitative proteomic analysis based on isobaric tag for relative and absolute quantitation (iTRAQ) and on–line 2D nano–liquid chromatography/tandem mass spectrometry (LC/MS/MS) to identify proteins differentially expressed during BMP–2–induced chondrogenic differentiation of MEFs. The findings illustrate epigenetic regulation of the chondrogenic differentiation process and also expand the understanding of the involved intracellular mechanisms.

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